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{userid:"kelly-alvarez", "refid":"15","repocollections":"","attachment":"","_thumb":"","articletype":"article","sectionheading":"","title":"Titanium implants after alkali heating treatment with a [Zn(OH)4]2 complex: analysis of interfacial bond strength  using push-out tests","year":"2010","author":"K. Alvarez, M. Fukuda, O. Yamamoto","journal":"Clin. Impl. Dent. Rel. Res.  ","volume":"12 Suppl. 1","number":"","pages":"e114-e125.","month":"","doi":"10.1111\/j.1708-8208.2010.00278.x","pubmed":"","pdflink":"","urllink":"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1708-8208.2010.00278.x\/abstract","abstract":"Background: Clinical demands for stronger and faster bone bonding to implants have motivated the development of chemically and topographically modified surfaces capable of chemical bonding. This study presents a new one-step alkali heat treatment performed with a solution containing [Zn(OH)4]2\u2212 complex as an alternative to the conventional NaOH solution.\r\n\r\nPurpose: The objective of this work is to assess the effect of a Zn-modified surface chemistry on bone-implant shear strength using a rabbit model.\r\n\r\nMaterials and Methods: The study was conducted on mechanical-grinded and smooth surfaces of Ti cylindrical implants. The topographical structure, chemical surface composition, and structural properties of the chemically modified titanium surface were studied by scanning electron microscopy, x-ray photoelectron spectroscopy, and x-ray diffractometry. Implant-bone shear strength was evaluated by push-out tests undertaken at 4, 12, and 24 weeks after insertion in rabbit femora.\r\n\r\nResults: Implants with smooth and rough surfaces chemically-modified with a solution containing [Zn(OH)4]2\u2212 complex demonstrated significantly stronger bone fixation than nonmodified implants at all healing times (p < 0.05).\r\n\r\nConclusions: The obtained results suggest that biochemical bonding at the bone-implant interface, stimulated by the Zn2+ ion release in combination with mechanical interlocking definitively improved the implant fixation.\r\n\r\n","note":"","tags":"biomechanical test;surface modification;titanium;Zn2+ ion-incorporated Ti implant;[Zn(OH)4]2\u2212 complex alkali heating"}
,

{userid:"kelly-alvarez", "refid":"16","repocollections":"","attachment":"","_thumb":"","articletype":"inproceedings","sectionheading":"","title":"In vitro and in vivo Characterization of Oxygen-infused Titanium","year":"2009","author":"K. Alvarez, Y. Kashiwaya, O. Yamamoto, M. Fukuda ","booktitle":"Proceedings of the 47th Basic Symposium on Basic Science of Ceramics,","editor":"Ceramic Society of Japan","pages":"132-133","organization":"","address":"","publisher":"","doi":"","pubmed":"","pdflink":"","urllink":"","abstract":"In this study novel oxygen-infused titanium, fabricated by introducing oxygen by heat treatment into the titanium crystal lattice was investigated. In vitro tests were performed to check cytotoxicity, examining cell morphology, cell proliferation and alkaline phosphatase activity. In vivo experiments involved implantation of cylindrical implants into a rabbit femoral bone. Interface shear strength was determined using a transcortical push-out model at 4 and 12 weeks after implantation. After the in vitro and in vivo evaluation it was concluded that the applied thermochemical treatment is effective for improving the biocompatibility of titanium, which was evidenced by the higher proliferation rates of osteoblasts, higher osteodiferentiation capability and superior interface shear strength.","note":"","tags":"push-out test, cell viability, cell mineralization"}
,

{userid:"j.a.alvarez-fernandez", "refid":"10","attachment":"","articletype":"article","sectionheading":"","title":"Clinical relevance of patent foramen ovale and right-to-left shunt","year":"2006","author":"J A Alvarez-Fern\u00e1ndez, O A Blasco, R P\u00e9rez-Quintero","journal":"Rev Clin Esp","volume":"206","number":"4","pages":"202-204","month":"Apr","doi":"","pubmed":"16750095","pdflink":"http:\/\/www.elsevier.es\/watermark\/ctl_servlet?_f=10&pident_articulo=13086805&pident_usuario=0&pcontactid=&pident_revista=65&fichero=65v206n04a13086805pdf001.pdf&ty=4&accion=L&origen=elsevier&web=www.elsevier.es&lan=es","urllink":"","abstract":"A frequent finding in healthy individuals, patent foramen ovale (PFO) with right-to-left shunt (RLSh), is an embrionary residue that has been linked with cryptogenic stroke and peripheral ischemia. Pulmonary hypertension and entities like decompression illness, migraine with aura or plathypnea-orthodeoxia have been found to have a higher prevalence of PFO with RLSh. Some dementias and unexplained syncopes could also have some relationship. Paradoxical embolism, thrombosis of the foramen channel or the atrial structures with subsequent embolism, transient arrhythmias, prothrombotic states and vasoactive substances passage have been proposed as physiopathologic mechanisms involved. Contrast-enhanced transesophageal echocardiography is the standard reference diagnostic procedure but contrast-enhanced transcranial Doppler is a good non-invasive alternative diagnostic tool that is highly sensitive and specific.","note":"","tags":"Heart Septal Defects, Atrial,Humans"}
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{userid:"j.a.alvarez-fernandez", "refid":"31","repocollections":"","attachment":"","_thumb":"","articletype":"article","sectionheading":"","title":"Contribution of the patent foramen ovale to the etiopathogeny of the irritable bowel syndrome.","year":"2009","author":"J A Alvarez-Fern\u00e1ndez, O Alarc\u00f3n-Fern\u00e1ndez, R P\u00e9rez-Quintero","journal":"Rev Clin Esp","volume":"209 (3)","number":"","pages":"136-40","month":"Mar","doi":"","pubmed":"19445849","pdflink":"http:\/\/www.elsevier.es\/watermark\/ctl_servlet?_f=10&pident_articulo=13136182&pident_usuario=0&pcontactid=&pident_revista=65&fichero=65v209n03a13136182pdf001.pdf&ty=133&accion=L&origen=elsevier&web=www.elsevier.es&lan=es","urllink":"","abstract":"A higher prevalence of cardiac right-to-left shunt through a patent foramen ovale (PFO) has been recently reported in the irritable bowel syndrome (IBS). At the same time, signs of ischemia in medullary cerebral microcirculation and the presence of excess sympathetic activity in peripheral circulation have been identified, both related with change in pain perception and autonomic dysfunction characteristic of IBS. Considering these findings together, the possible etiopathogenic role of PFO in the development of IBS can be proposed, because the paradoxical embolism characteristic of PFO could damage the cerebral and intestinal microcirculation, and that injury would be also amplified by the percentage of venous blood that shunts the pulmonary filter, producing an alteration in the metabolism of serotonin, pro-inflammatory bradykinins or neurotensin, substances with a proven etiopathogenic relationship with IBS.","note":"","tags":""}
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{userid:"catai", "articletype":"article","pages":"241-3","author":"O Ferrer-Roca, H Alvarez-Arguelles, J Castaneda, E Gonzalez-Reimers, M Pestana, L Hernandez Nieto","year":"1984","title":"Nodular sclerosis-type Hodgkin's disease and its development into lymphocytic depletion","month":"1984","journal":"Rev Clin Esp","publisher":"","volume":"175","number":"5-6","note":"","tags":"","booktitle":"","editor":"","abstract":"","address":"","school":"","issn":"0014-2565","doi":"","isi":"","pubmed":"","key":"Ferrer-Roca1984","howpublished":"","urllink":"","refid":127}
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{userid:"j.a.alvarez-fernandez", "refid":"4","attachment":"","_thumb":"","articletype":"article","sectionheading":"","title":"Ischemic colitis and patent foramen oval","year":"2007","author":"JA Alvarez-Fern\u00e1ndez, A S\u00e1nchez Del R\u00edo, R P\u00e9rez-Quintero, O Alarc\u00f3n-Fern\u00e1ndez","journal":"Med Clin (Barc)","volume":"129","number":"","pages":"679","month":"Nov","doi":"","pubmed":"18005639","pdflink":"","urllink":"","abstract":"","note":"","tags":"Aged,Colitis, Ischemic,Colonoscopy,Echocardiography,Electrocardiography,Female,Foramen Ovale, Patent,Humans"}
,

{userid:"kelly-alvarez", "refid":"7","repocollections":"","attachment":"","_thumb":"","articletype":"article","sectionheading":"","title":"Fabrication and characterization of oxygen-diffused titanium for biomedical applications","year":"2009","author":"O. Yamamoto, K. Alvarez, T. Kikuchi, M. Fukuda","journal":"Acta Biomater. ","volume":"5 (9)","number":"","pages":"3605-3615.","month":"","doi":"doi:10.1016\/j.actbio.2009.06.011    ","pubmed":"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19523543","pdflink":"http:\/\/www.actabiomat.org\/article\/PIIS1742706109002633\/abstract","urllink":"","abstract":"Although titanium has been successful as an orthopedic or dental implant material, performance problems still persist concerning implant\u2013bone interfacial bonding strength. In this study a novel oxygen-diffused titanium (ODTi), fabricated by introducing oxygen into the titanium crystal lattice by thermal treatment, was investigated. The fabricated material is the result of a surface modification made on commercially pure titanium (cp Ti) previously coated with poly(vinyl alcohol) (PVA) by means of a thermal treatment performed at 700\u00b0C in an ultra-pure argon atmosphere. The thermal treatment at 700\u00b0C led to the formation of an anatase TiO2 film on the cp Ti surface and a concentration gradient of oxygen into titanium. The surface of the fabricated ODTi consisted of an outer nanometric layer of anatase TiO2 and an inner nanometric layer of Ti2Ox (x<1) in which the oxygen is in solid solution with the titanium metal. It was found that ODTi possesses in vitro apatite formation ability after being soaked into simulated body fluid (SBF) solution. This apatite formation ability is attributed to the presence of the anatase TiO2 outermost surface layer and to abundant hydroxyl groups (\u2013OH) formed on the ODTi surface after immersion in SBF.\r\n\r\n","note":"","tags":"Oxygen-diffused titanium, Anatase TiO2, Thermal oxidation, Simulated body fluid, Bioactivity"}
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{userid:"kelly-alvarez", "refid":"14","repocollections":"","attachment":"","_thumb":"","articletype":"article","sectionheading":"","title":"Antibacterial characteristics of CaCO3-MgO composites","year":"2010","author":"O. Yamamoto, T. Ohira, K. Alvarez, M. Fukuda","journal":"Mater. Sci. Eng. B ","volume":"173","number":"","pages":"208-212.","month":"","doi":"10.1016\/j.mseb.2009.12.007","pubmed":"","pdflink":"http:\/\/www.sciencedirect.com\/science?_ob=ArticleURL&_udi=B6TXF-4Y062H5-7&_user=4545549&_coverDate=12%2F21%2F2009&_alid=1144950550&_rdoc=1&_fmt=high&_orig=search&_cdi=5589&_sort=r&_docanchor=&view=c&_ct=10&_acct=C000008298&_version=1&_urlVersion=0&_userid=4545549&md5=0a9b06b4cc84c336d61d47b0fbd5c187","urllink":"","abstract":"Dentifrices, such as tooth-paste, are pastes containing insoluble abrasives that aid in the removal of plaque from the teeth and help to polish them. Composite powders contributing to oral hygiene application, i.e., nano-scale MgO crystallite dispersed in CaCO3 grain, were fabricated by the thermal decomposition of dolomite. The composite obtained by heating at 800 \u00b0C consisted of CaCO3 grains including 20 nm MgO fine crystallite, being the purpose powder in this study. The antibacterial activity of these powders related to gram-positive and gram-negative bacteria was evaluated in vitro. The thermal decomposition above 800 \u00b0C resulted in the mixture of CaO and MgO. Antibacterial activity of the composite enhanced with increasing powder concentration. Though antibacterial action toward Staphylococcus aureus was greater than towards Escherichia coli, the death rate constant was identical in both bacteria. It can be concluded that the obtained composite possesses two functions able to improve the oral hygiene: as a tooth abrasive and as an antibacterial agent.\r\n\r\n","note":"","tags":"Composite; CaCO3; MgO; Antibacterial activity; Oral hygiene application"}
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{userid:"kelly-alvarez", "refid":"17","repocollections":"","attachment":"","_thumb":"","articletype":"article","sectionheading":"","title":"Significant effect of a carbon layer coating on interfacial bond\r\nstrength between bone and Ti implant","year":"2011","author":"O. Yamamoto, K. Alvarez, Y. Kashiwaya, M. Fukuda","journal":"Carbon","volume":"49","number":"5","pages":"1588-1598","month":"","doi":"doi:10.1016\/j.carbon.2010.12.041  ","pubmed":"","pdflink":"http:\/\/www.sciencedirect.com\/science?_ob=ArticleURL&_udi=B6TWD-51R0781-3&_user=10&_coverDate=04%2F30%2F2011&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_searchStrId=1641499508&_rerunOrigin=google&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=3c0a88158d1255c5449431f39109c655&searchtype=a","urllink":"","abstract":"We investigated the degree of osseointegration in carbon-coated oxygen-diffused titanium\r\nimplants (C-ODTi) by means of biomechanical tests of the femoral bones of rabbits. C-ODTi\r\npossesses interstitial oxygen atoms into the host titanium lattice and an upper nanometric\r\nsurface layer of anatase-TiO2 covered with 20 nm carbon layer. Interface shear strength was\r\ndetermined by using a transcortical push-out model at 4, 12 and 24 weeks after implantation.\r\nImplants with different surfaces were prepared, including a carbon coating and an\r\nabrasion treatment. There was a significant improvement in the bone-bonding shear\r\nstrength for the C-ODTi. The highest shear strength values were observed in the C-ODTi\r\ngroup at 24 weeks and differed significantly from those of the control group at the same\r\nexperimental time (p < 0.05). After the in vivo evaluation it was concluded that the coating\r\nof a carbon layer on the surface of titanium implant was effective for improving the biocompatibility\r\nof titanium, which was evidenced by the superior interface shear strength.","note":"","tags":"carbon-coated oxygen-diffused titanium, implant, interfacial bond strength"}
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{userid:"kelly-alvarez", "refid":"18","repocollections":"","attachment":"","_thumb":"","articletype":"article","sectionheading":"","title":"Surface characterization and biological response of carbon-coated oxygen-diffused titanium having different topographical surfaces \r\n","year":"2011","author":"O. Yamamoto, K. Alvarez, Y. Kashiwaya, M. Fukuda\r\n\r\n","journal":"J. Mater. Sci. Mater. Med.","volume":"22","number":"4","pages":"977-987","month":"","doi":"10.1007\/s10856-011-4267-x","pubmed":"21365295","pdflink":"http:\/\/www.springerlink.com\/content\/e1376004477nn811\/","urllink":"","abstract":"The materials (C-ODTi) with different topographical\r\nsurfaces that possess interstitial oxygen atoms\r\ninto the host titanium lattice and an upper nanometric\r\nsurface layer of anatase-TiO2 covered by a carbon thin\r\nlayer were fabricated in this study. The carbon thin layer on\r\nthe surface of C-ODTi was composed of amorphous carbon\r\nand nano-graphite crystals. In vitro tests, using human bone\r\nmarrow-derived mesenchymal cells (hBMCs), were performed\r\nto check cytotoxicity, examining in particular cell\r\nmorphology, cell proliferation, cell differentiation, and\r\nmineralization capability. After 10 days of culture a higher\r\ndegree of cell viability was observed on the surface of\r\nC-ODTi with an abraded surface. We also observed that\r\nhBMCs cultured in direct contact with C-ODTi maintained\r\ntheir capability to express alkaline phosphatase activity\r\n(ALP) and formed mineralized nodules similar to the\r\ncontrol cultures. Our results demonstrate that the carbon\r\nlayer coating on the surface of C-ODTi possess better\r\nbiological response than commercially pure titanium (cp\r\nTi), which was evidenced by the higher proliferation rates\r\nof osteoblasts, higher osteo-differentiation and a higher\r\nmineralization capability.","note":"","tags":"hBMCs, in vitro biocompatibility, C-ODTi","weight":"18"}
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