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{userid:"salvador.sarro", "refid":"28","repocollections":"","attachment":"","_thumb":"","articletype":"article","sectionheading":"","title":"First-episode psychosis is characterized by failure of deactivation but not by hypo- or hyperfrontality.","year":"2012","author":"A Guerrero-Pedraza, P J McKenna, J J Gomar, S Sarr\u00f3, R Salvador, B Amann, M I Carri\u00f3n, R Landin-Romero, J Blanch, E Pomarol-Clotet","journal":"Psychol Med","volume":"42","number":"1","pages":"73-84","month":"Jan","doi":"10.1017\/S0033291711001073","pubmed":"21733286","pdflink":"","urllink":"","abstract":"It is not known whether first-episode psychosis is characterized by the same prefrontal cortex functional imaging abnormalities as chronic schizophrenia.","note":"","tags":"","publisher":"","booktitle":"","editor":"","address":"","school":"","issn":"1469-8978","isi":"","key":"Guerrero-Pedraza2012","howpublished":""}
,

{userid:"salvador.sarro", "refid":"33","repocollections":"","attachment":"","_thumb":"","articletype":"article","sectionheading":"","title":"Brain functional abnormality in schizo-affective disorder: an fMRI study.","year":"2013","author":"M Madre, E Pomarol-Clotet, P McKenna, J Radua, J Ortiz-Gil, F Panicali, J M Goikolea, E Vieta, S Sarr\u00f3, R Salvador, B L Amann","journal":"Psychol Med","volume":"43","number":"1","pages":"143-153","month":"Jan","doi":"10.1017\/S0033291712000943","pubmed":"22583916","pdflink":"","urllink":"","abstract":"Schizo-affective disorder has not been studied to any significant extent using functional imaging. The aim of this study was to examine patterns of brain activation and deactivation in patients meeting strict diagnostic criteria for the disorder.","note":"","tags":"","publisher":"","booktitle":"","editor":"","address":"","school":"","issn":"1469-8978","isi":"","key":"Madre2013","howpublished":""}
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{userid:"ejcanalesr", "articletype":"article","pages":"16-30","author":"M Madre, E J Canales-Rodr\u00edguez, J Ortiz-Gil, A Murru, C Torrent, E Bramon, V Perez, M Orth, P Brambilla, E Vieta, B L Amann","year":"2016","title":"Neuropsychological and neuroimaging underpinnings of schizoaffective disorder: a systematic review.","month":"07","journal":"Acta psychiatrica Scandinavica","publisher":"","volume":"134","number":"1","note":"","tags":"Brain Mapping,Diffusion Magnetic Resonance Imaging,Gray Matter,Humans,Neuroimaging,Psychotic Disorders","booktitle":"","editor":"","abstract":"The neurobiological basis and nosological status of schizoaffective disorder remains elusive and controversial. This study provides a systematic review of neurocognitive and neuroimaging findings in the disorder.","address":"","school":"","issn":"1600-0447","doi":"10.1111\/acps.12564","isi":"","pubmed":"27028168","key":"Madre2016","howpublished":"","urllink":"","refid":58,"weight":58}
,

{userid:"j.radua", "articletype":"article","pages":"143-153","author":"M Madre, E Pomarol-Clotet, P McKenna, J Radua, J Ortiz-Gil, F Panicali, J M Goikolea, E Vieta, S Sarr\u00f3, R Salvador, B L Amann","year":"2013","title":"Brain functional abnormality in schizo-affective disorder: an fMRI study.","month":"Jan","journal":"Psychological medicine","publisher":"","volume":"43","number":"1","note":"","tags":"Adult,Brain,Female,Humans,Magnetic Resonance Imaging,Male,Memory, Short-Term,Middle Aged,Nerve Net,Neuropsychological Tests,Psychotic Disorders","booktitle":"","editor":"","abstract":"Schizo-affective disorder has not been studied to any significant extent using functional imaging. The aim of this study was to examine patterns of brain activation and deactivation in patients meeting strict diagnostic criteria for the disorder.","address":"","school":"","issn":"1469-8978","doi":"10.1017\/S0033291712000943","isi":"","pubmed":"22583916","key":"Madre2013","howpublished":"","urllink":"","refid":16}
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{userid:"salvador.sarro", "refid":"30","repocollections":"","attachment":"","_thumb":"","articletype":"article","sectionheading":"","title":"Executive dysfunction and memory impairment in schizoaffective disorder: a comparison with bipolar disorder, schizophrenia and healthy controls.","year":"2012","author":"B Amann, J J Gomar, J Ortiz-Gil, P McKenna, B Sans-Sansa, S Sarr\u00f3, N Moro, M Madre, R Landin-Romero, E Vieta, J M Goikolea, J M Giokolea, R Salvador, E Pomarol-Clotet","journal":"Psychol Med","volume":"42","number":"10","pages":"2127-2135","month":"Oct","doi":"10.1017\/S0033291712000104","pubmed":"22357405","pdflink":"","urllink":"","abstract":"Deficits in memory and executive performance are well-established features of bipolar disorder and schizophrenia. By contrast, data on cognitive impairment in schizoaffective disorder are scarce and the findings are conflicting.","note":"","tags":"","publisher":"","booktitle":"","editor":"","address":"","school":"","issn":"1469-8978","isi":"","key":"Amann2012","howpublished":""}
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{userid:"jana.ortmann", "articletype":"article","pages":"974-981","author":"Jana Ortmann, Kerstin Amann, Ralf P Brandes, Matthias Kretzler, Klaus M\u00fcnter, Niranjan Parekh, Tobias Traupe, Melanie Lange, Thomas Lattmann, Matthias Barton","year":"2004","title":"Role of podocytes for reversal of glomerulosclerosis and proteinuria in the aging kidney after endothelin inhibition.","month":"Dec","journal":"Hypertension","publisher":"","volume":"44","number":"6","note":"","tags":"Aging,Animals,Apoptosis,Blood Pressure,Cell Cycle Proteins,Cyclin-Dependent Kinase Inhibitor p21,DNA,Disease Models, Animal,Endothelin-1,Gene Expression,Gene Silencing,Glomerular Filtration Rate,Glomerulosclerosis, Focal Segmental,Kidney,Kidney Glomerulus,Male,Matrix Metalloproteinase 9,Phenylpropionates,Proteinuria,Pyrimidines,Rats,Rats, Wistar,Receptor, Endothelin A,Signal Transduction","booktitle":"","editor":"","abstract":"The cause of focal-segmental glomerulosclerosis as a consequence of physiological aging, which is believed to be inexorable, is unknown. This study investigated whether inhibition of endothelin-1, a growth-promoting peptide contributing to renal injury in hypertension and diabetes, affects established glomerulosclerosis and proteinuria in the aged kidney. We also determined the role of endothelin receptors for podocyte injury in vivo and in vitro. Aged Wistar rats, a model of spontaneous age-dependent glomerulosclerosis, were treated with the orally active endothelin subtype A (ET(A)) receptor antagonist darusentan, and evaluation of renal histology, renal function studies, and expression analyses were performed. In vitro experiments using puromycin aminonucleoside to induce podocyte injury investigated the role of ET(A) receptor signaling for apoptosis, cytoskeletal injury, and DNA synthesis. In aged Wistar rats, established glomerulosclerosis and proteinuria were reduced by >50% after 4 weeks of darusentan treatment, whereas blood pressure, glomerular filtration rate, or tubulo-interstitial renal injury remained unaffected. Improvement of structural injury in glomeruli and podocytes was accompanied by a reduction of the expression of matrix metalloproteinase-9 and p21Cip1\/WAF1. In vitro experiments blocking ET(A) receptors using specific antagonists or RNA interference prevented apoptosis and structural damage to podocytes induced by puromycin aminonucleoside. In conclusion, these results support the hypothesis that endogenous endothelin contributes to glomerulosclerosis and proteinuria in the aging kidney. The results further suggest that age-dependent glomerulosclerosis is not merely a \"degenerative\" but a reversible process locally confined to the glomerulus involving recovery of podocytes from previous injury.","address":"","school":"","issn":"1524-4563","doi":"10.1161\/01.HYP.0000149249.09147.b4","isi":"","pubmed":"15545511","key":"Ortmann2004","howpublished":"","urllink":"","refid":13}
,

{userid:"traupe", "refid":"13","repocollections":"","attachment":"","_thumb":"","articletype":"article","sectionheading":"ORIGINAL RESEARCH PAPERS","title":"Role of podocytes for reversal of glomerulosclerosis and proteinuria in the aging kidney after endothelin inhibition.","year":"2004","author":"Jana Ortmann, Kerstin Amann, Ralf P Brandes, Matthias Kretzler, Klaus M\u00fcnter, Niranjan Parekh, Tobias Traupe, Melanie Lange, Thomas Lattmann, Matthias Barton","journal":"Hypertension","volume":"44","number":"6","pages":"974-981","month":"Dec","doi":"10.1161\/01.HYP.0000149249.09147.b4","pubmed":"15545511","pdflink":"","urllink":"","abstract":"The cause of focal-segmental glomerulosclerosis as a consequence of physiological aging, which is believed to be inexorable, is unknown. This study investigated whether inhibition of endothelin-1, a growth-promoting peptide contributing to renal injury in hypertension and diabetes, affects established glomerulosclerosis and proteinuria in the aged kidney. We also determined the role of endothelin receptors for podocyte injury in vivo and in vitro. Aged Wistar rats, a model of spontaneous age-dependent glomerulosclerosis, were treated with the orally active endothelin subtype A (ET(A)) receptor antagonist darusentan, and evaluation of renal histology, renal function studies, and expression analyses were performed. In vitro experiments using puromycin aminonucleoside to induce podocyte injury investigated the role of ET(A) receptor signaling for apoptosis, cytoskeletal injury, and DNA synthesis. In aged Wistar rats, established glomerulosclerosis and proteinuria were reduced by >50% after 4 weeks of darusentan treatment, whereas blood pressure, glomerular filtration rate, or tubulo-interstitial renal injury remained unaffected. Improvement of structural injury in glomeruli and podocytes was accompanied by a reduction of the expression of matrix metalloproteinase-9 and p21Cip1\/WAF1. In vitro experiments blocking ET(A) receptors using specific antagonists or RNA interference prevented apoptosis and structural damage to podocytes induced by puromycin aminonucleoside. In conclusion, these results support the hypothesis that endogenous endothelin contributes to glomerulosclerosis and proteinuria in the aging kidney. The results further suggest that age-dependent glomerulosclerosis is not merely a \"degenerative\" but a reversible process locally confined to the glomerulus involving recovery of podocytes from previous injury.","note":"","tags":"Aging,Animals,Apoptosis,Blood Pressure,Cell Cycle Proteins,Cyclin-Dependent Kinase Inhibitor p21,DNA,Disease Models, Animal,Endothelin-1,Gene Expression,Gene Silencing,Glomerular Filtration Rate,Glomerulosclerosis, Focal Segmental,Kidney,Kidney Glomerulus,Male,Matrix Metalloproteinase 9,Phenylpropionates,Proteinuria,Pyrimidines,Rats,Rats, Wistar,Receptor, Endothelin A,Signal Transduction","howpublished":"","publisher":"","booktitle":"","editor":"","address":"","school":"","issn":"1524-4563","isi":"","key":"Ortmann2004"}
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{userid:"amannvc", "refid":"6","repocollections":"","attachment":"","_thumb":"","articletype":"article","sectionheading":"","title":"Multicenter, real-life experience with checkpoint inhibitors and targeted therapy agents in advanced melanoma patients in Switzerland.","year":"2017","author":"Joanna Mangana, Phil F Cheng, Corina Kaufmann, Valerie C Amann, Anna L Frauchiger, Viola St\u00f6gner, Ulrike Held, Roger von Moos, Olivier Michielin, Ralph P Braun, Mitchell P Levesque, Simone M Goldinger, Reinhard Dummer","journal":"Melanoma research","volume":"27","number":"4","pages":"358-368","month":"08","doi":"10.1097\/CMR.0000000000000359","pubmed":"28509765","pdflink":"","urllink":"","abstract":"Metastatic melanoma is a highly aggressive disease. Recent progress in immunotherapy (IT) and targeted therapy (TT) has led to significant improvements in response and survival rates in metastatic melanoma patients. The current project aims to determine the benefit of the introduction of these new therapies in advanced melanoma across several regions of Switzerland. This is a retrospective multicenter analysis of 395 advanced melanoma patients treated with standard chemotherapy, checkpoint inhibitors, and kinase inhibitors from January 2008 until December 2014. The 1-year survival was 69% (n=121) in patients treated with checkpoint inhibitors (IT), 50% in patients treated with TTs (n=113), 85% in the IT+TT group (n=66), and 38% in patients treated with standard chemotherapy (n=95). The median overall survival (mOS) from first systemic treatment in the entire study cohort was 16.9 months. mOS of patients treated either with checkpoint or kinase inhibitors (n=300, 14.6 months) between 2008 and 2014 was significantly improved (P<0.0001) compared with patients treated with standard chemotherapy in 2008-2009 (n=95, 7.4 months). mOS of 61 patients with brain metastases at stage IV was 8.1 versus 12.5 months for patients without at stage IV (n=334), therefore being significantly different (P=0.00065). Furthermore, a significant reduction in hospitalization duration compared with chemotherapy was noted. Treatment with checkpoint and kinase inhibitors beyond clinical trials significantly improves the mOS in real life and the results are consistent with published prospective trial data.","note":"","tags":"Antibodies, Monoclonal,Cohort Studies,Humans,Immunotherapy,Melanoma,Middle Aged,Retrospective Studies,Skin Neoplasms,Switzerland","weight":6,"publisher":"","booktitle":"","editor":"","address":"","school":"","issn":"1473-5636","isi":"","key":"Mangana2017","howpublished":""}
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{userid:"amannvc", "refid":"4","repocollections":"","attachment":"","_thumb":"","articletype":"article","sectionheading":"","title":"Unexpected contribution of lymphatic vessels to promotion of distant metastatic tumor spread.","year":"2018","author":"Qiaoli Ma, Lothar C Dieterich, Kristian Ikenberg, Samia B Bachmann, Johanna Mangana, Steven T Proulx, Valerie C Amann, Mitchell P Levesque, Reinhard Dummer, Peter Baluk, Donald M McDonald, Michael Detmar","journal":"Science advances","volume":"4","number":"8","pages":"","month":"08","doi":"10.1126\/sciadv.aat4758","pubmed":"30101193","pdflink":"","urllink":"","abstract":"Tumor lymphangiogenesis is accompanied by a higher incidence of sentinel lymph node metastasis and shorter overall survival in several types of cancer. We asked whether tumor lymphangiogenesis might also occur in distant organs with established metastases and whether it might promote further metastatic spread of those metastases to other organs. Using mouse metastasis models, we found that lymphangiogenesis occurred in distant lung metastases and that some metastatic tumor cells were located in lymphatic vessels and draining lymph nodes. In metastasis-bearing lungs of melanoma patients, a higher lymphatic density within and around metastases and lymphatic invasion correlated with poor outcome. Using a transgenic mouse model with inducible expression of vascular endothelial growth factor C (VEGF-C) in the lung, we found greater growth of lung metastases, with more abundant dissemination to other organs. Our findings reveal unexpected contributions of lymphatics in distant organs to the promotion of growth of metastases and their further spread to other organs, with potential clinical implications for adjuvant therapies in patients with metastatic cancer.","note":"","tags":"Animals,Breast Neoplasms,Female,Humans,Lung Neoplasms,Lymphangiogenesis,Lymphatic Metastasis,Lymphatic Vessels,Melanoma, Experimental,Mice,Mice, Inbred BALB C,Mice, Inbred C57BL,Neovascularization, Pathologic,Prognosis,Retrospective Studies,Survival Rate,Tumor Cells, Cultured,Vascular Endothelial Growth Factor A,Vascular Endothelial Growth Factor C","weight":4,"publisher":"","booktitle":"","editor":"","address":"","school":"","issn":"2375-2548","isi":"","key":"Ma2018","howpublished":""}
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{userid:"j.radua", "articletype":"article","pages":"23-33","author":"B L Amann, E J Canales-Rodr\u00edguez, M Madre, J Radua, G Monte, S Alonso-Lana, R Landin-Romero, A Moreno-Alc\u00e1zar, C M Bonnin, S Sarr\u00f3, J Ortiz-Gil, J J Gomar, N Moro, P Fernandez-Corcuera, J M Goikolea, J Blanch, R Salvador, E Vieta, P J McKenna, E Pomarol-Clotet","year":"2016","title":"Brain structural changes in schizoaffective disorder compared to schizophrenia and bipolar disorder.","month":"Jan","journal":"Acta psychiatrica Scandinavica","publisher":"","volume":"133","number":"1","note":"","tags":"Adult,Bipolar Disorder,Brain,Brain Mapping,Case-Control Studies,Diffusion Magnetic Resonance Imaging,Female,Gray Matter,Humans,Male,Middle Aged,Neuroimaging,Psychotic Disorders,Schizophrenia","booktitle":"","editor":"","abstract":"Brain structural changes in schizoaffective disorder, and how far they resemble those seen in schizophrenia and bipolar disorder, have only been studied to a limited extent.","address":"","school":"","issn":"1600-0447","doi":"10.1111\/acps.12440","isi":"","pubmed":"25968549","key":"Amann2016","howpublished":"","urllink":"","refid":64,"weight":64}
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