// +author:s ansart +author:ansart 
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{userid:"yves.renaudineau", "articletype":"article","pages":"170-175","author":"S Croquefer, Y Renaudineau, S Jousse, P Gueguen, S Ansart, A Saraux, P Youinou","year":"2005","title":"The ananti-alpha-actinin test completes ananti-DNA determination in systemic lupus erythematosus.","month":"Jun","journal":"Annals of the New York Academy of Sciences","publisher":"","volume":"1050","number":"","note":"","tags":"Actinin,Antibodies, Antinuclear,Blotting, Western,DNA,Enzyme-Linked Immunosorbent Assay,Humans,Immunoglobulin G,Lupus Erythematosus, Systemic,Lupus Nephritis","booktitle":"","editor":"","abstract":"In murine systemic lupus erythematosus (SLE) models, nephritogenic anti-dsDNA IgG has been shown to cross-react with a kidney antigen, alpha-actinin, and to be critical in renal pathogenesis. In humans, studies of anti-alpha-actinin antibodies (Abs) are scarce, and these antibodies remain to be evaluated. We have thus far tested sera from patients with SLE (n = 103), rheumatoid arthritis (RA, n = 93), and primary Sj\u00f6gren syndrome (pSS, n = 34), and from healthy subjects (n = 160), for the presence of anti-alpha-actinin and anti-DNA Abs. The latter were tested using several methods [IIF on Crithidia luciliae (Crit) and ELISA using dsDNA]. Anti-alpha-actinin Abs were confirmed by Western blot. Sera from 23 of 103 SLE patients, 3 of 93 RA patients, 1 of 33 pSS patients, and 1 of 160 controls scored positive for anti-alpha-actinin Abs. In SLE, the positivity was significantly associated with anti-dsDNA reactivity (22 of 23): 19 of 23 sera were alpha-actinin-positive\/dsDNA-positive and 13 were alpha-actinin-positive\/Crit-positive. Few cases were alpha-actinin-positive\/dsDNA-negative: 1 SLE, 3 RA, and 1 control. Furthermore, anti-alpha-actinin Abs have been detected at high level before or at the early stage of lupus nephritis when compared with active and inactive SLE without kidney manifestations.","address":"","school":"","issn":"0077-8923","doi":"10.1196\/annals.1313.017","isi":"","pubmed":"16014531","key":"Croquefer2005","howpublished":"","urllink":"","refid":43,"weight":43}
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