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{userid:"aroon_melwani", "refid":"9","repocollections":"","attachment":"","_thumb":"","articletype":"techreport","sectionheading":"","title":"Mercury and PCBs in Small Fish 2005 - 2010","year":"2011","author":"B K Greenfield, R Allen, A R Melwani, K Ridolfi, K Harrold, D Slotton, S Ayers","institution":"","series":"","number":"","address":"","doi":"","pubmed":"","pdflink":"","urllink":"","abstract":"","note":"","tags":"","pages":"","month":"","journal":"","publisher":"","volume":"","booktitle":"","editor":"","school":"","issn":"","isi":"","key":"Greenfield2011","howpublished":""}
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{userid:"p_v", "articletype":"misc","pages":"6-21","author":"S. Ayers, B. Jr Roschek, J.M. Williams, R.S. Alberte","year":"","title":"Pharmacokinetic analysis of anti-allergy and anti-inflammation bioactives in a nettle (Urtica dioica) extract.","month":"","journal":"","publisher":"","volume":"5","number":"","note":"","tags":"AccuTOF","booktitle":"","editor":"","abstract":"Pharmacokinetic analyses were conducted using DART TOF-MS on the uptake of bioactive components present in a nettle (Urtica dioica) extract delivered orally as a lozenge. Previously adenine, synephrine, osthole, and nicotinamide were shown to be key bioactives contributing to the anti-inflammatory and anti-allergy properties of the nettle extract (Roschek et al, 2009). Average serum concentrations of adenine reached 35.2 nmol L-1, nicotinamide reached 8.7 nmol L-1, osthole reached 11.0 nmol L-1, and synephrine reached 107.4 nmol L-1. These serum levels are equivalent to 0.3%, 0.2%, 0.2%, and 1.6% oral bioavailability for adenine, synephrine, osthole and nicotinamide respectively. Urine concentrations for adenine, nicotinamide, synephrine, and osthole reached 4.9 nmol L-1, 2.5 nmol L-1, 6.6 nmol L-1, and 0.2 nmol L-1, respectively. The major pharmacokinetic parameters (Cmax, Tmax, T1\/2) were determined and compared for serum and urine. For all three of the compounds, Cmax values decreased 2- to 16-fold in urine compared to serum, Tmax values increased 2- to 12-fold, and T1\/2 values increased 2- to 10-fold. Molecular modeling revealed that these compounds were not likely to cross the blood-brain barrier, particularly important for the anti-histamine bioactives to ensure a non-drowsy activity. These results show that antiinflammatory and anti-allergenic compounds in nettle are readily absorbed into the body and excreted in the urine when a nettle extract is delivered orally as a lozenge. In addition, DART TOF-MS is useful in quantifying multiple components in biological matrices with little or no sample preparation.","address":"","school":"","issn":"","doi":"","isi":"","pubmed":"","key":"","howpublished":"","urllink":"","refid":602,"weight":602}
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{userid:"p_v", "articletype":"article","pages":"6-21","author":"S Ayers, B Jr Roschek, J M Williams, R S Alberte","year":"","title":"Pharmacokinetic analysis of anti-allergy and anti-inflammation bioactives in a nettle (Urtica dioica) extract.","month":"","journal":"","publisher":"","volume":"5","number":"","note":"","tags":"AccuTOF","booktitle":"","editor":"","abstract":"Pharmacokinetic analyses were conducted using DART TOF-MS on the uptake of bioactive components present in a nettle (Urtica dioica) extract delivered orally as a lozenge. Previously adenine, synephrine, osthole, and nicotinamide were shown to be key bioactives contributing to the anti-inflammatory and anti-allergy properties of the nettle extract (Roschek et al, 2009). Average serum concentrations of adenine reached 35.2 nmol L-1, nicotinamide reached 8.7 nmol L-1, osthole reached 11.0 nmol L-1, and synephrine reached 107.4 nmol L-1. These serum levels are equivalent to 0.3%, 0.2%, 0.2%, and 1.6% oral bioavailability for adenine, synephrine, osthole and nicotinamide respectively. Urine concentrations for adenine, nicotinamide, synephrine, and osthole reached 4.9 nmol L-1, 2.5 nmol L-1, 6.6 nmol L-1, and 0.2 nmol L-1, respectively. The major pharmacokinetic parameters (Cmax, Tmax, T1\/2) were determined and compared for serum and urine. For all three of the compounds, Cmax values decreased 2- to 16-fold in urine compared to serum, Tmax values increased 2- to 12-fold, and T1\/2 values increased 2- to 10-fold. Molecular modeling revealed that these compounds were not likely to cross the blood-brain barrier, particularly important for the anti-histamine bioactives to ensure a non-drowsy activity. These results show that antiinflammatory and anti-allergenic compounds in nettle are readily absorbed into the body and excreted in the urine when a nettle extract is delivered orally as a lozenge. In addition, DART TOF-MS is useful in quantifying multiple components in biological matrices with little or no sample preparation.","address":"","school":"","issn":"","doi":"","isi":"","pubmed":"","key":"ayers_pharmacokinetic_2008","howpublished":"","urllink":"","refid":1539,"weight":1539}
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{userid:"p_v", "articletype":"article","pages":"6-21","author":"S Ayers, B Jr Roschek, J M Williams, R S Alberte","year":"","title":"Pharmacokinetic analysis of anti-allergy and anti-inflammation bioactives in a nettle (Urtica dioica) extract.","month":"","journal":"","publisher":"","volume":"5","number":"","note":"","tags":"AccuTOF","booktitle":"","editor":"","abstract":"Pharmacokinetic analyses were conducted using DART TOF-MS on the uptake of bioactive components present in a nettle (Urtica dioica) extract delivered orally as a lozenge. Previously adenine, synephrine, osthole, and nicotinamide were shown to be key bioactives contributing to the anti-inflammatory and anti-allergy properties of the nettle extract (Roschek et al, 2009). Average serum concentrations of adenine reached 35.2 nmol L-1, nicotinamide reached 8.7 nmol L-1, osthole reached 11.0 nmol L-1, and synephrine reached 107.4 nmol L-1. These serum levels are equivalent to 0.3%, 0.2%, 0.2%, and 1.6% oral bioavailability for adenine, synephrine, osthole and nicotinamide respectively. Urine concentrations for adenine, nicotinamide, synephrine, and osthole reached 4.9 nmol L-1, 2.5 nmol L-1, 6.6 nmol L-1, and 0.2 nmol L-1, respectively. The major pharmacokinetic parameters (Cmax, Tmax, T1\/2) were determined and compared for serum and urine. For all three of the compounds, Cmax values decreased 2- to 16-fold in urine compared to serum, Tmax values increased 2- to 12-fold, and T1\/2 values increased 2- to 10-fold. Molecular modeling revealed that these compounds were not likely to cross the blood-brain barrier, particularly important for the anti-histamine bioactives to ensure a non-drowsy activity. These results show that antiinflammatory and anti-allergenic compounds in nettle are readily absorbed into the body and excreted in the urine when a nettle extract is delivered orally as a lozenge. In addition, DART TOF-MS is useful in quantifying multiple components in biological matrices with little or no sample preparation.","address":"","school":"","issn":"","doi":"","isi":"","pubmed":"","key":"ayers_pharmacokinetic_2008","howpublished":"","urllink":"","refid":1850,"weight":1850}
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{userid:"p_v", "articletype":"article","pages":"6-21","author":"S Ayers, B Jr Roschek, J M Williams, R S Alberte","year":"2008","title":"","month":"","journal":"","publisher":"","volume":"5","number":"","note":"","tags":"AccuTOF","booktitle":"","editor":"","abstract":"Pharmacokinetic analyses were conducted using DART TOF-MS on the uptake of bioactive components present in a nettle (Urtica dioica) extract delivered orally as a lozenge. Previously adenine, synephrine, osthole, and nicotinamide were shown to be key bioactives contributing to the anti-inflammatory and anti-allergy properties of the nettle extract (Roschek et al, 2009). Average serum concentrations of adenine reached 35.2 nmol L-1, nicotinamide reached 8.7 nmol L-1, osthole reached 11.0 nmol L-1, and synephrine reached 107.4 nmol L-1. These serum levels are equivalent to 0.3%, 0.2%, 0.2%, and 1.6% oral bioavailability for adenine, synephrine, osthole and nicotinamide respectively. Urine concentrations for adenine, nicotinamide, synephrine, and osthole reached 4.9 nmol L-1, 2.5 nmol L-1, 6.6 nmol L-1, and 0.2 nmol L-1, respectively. The major pharmacokinetic parameters (Cmax, Tmax, T1\/2) were determined and compared for serum and urine. For all three of the compounds, Cmax values decreased 2- to 16-fold in urine compared to serum, Tmax values increased 2- to 12-fold, and T1\/2 values increased 2- to 10-fold. Molecular modeling revealed that these compounds were not likely to cross the blood-brain barrier, particularly important for the anti-histamine bioactives to ensure a non-drowsy activity. These results show that antiinflammatory and anti-allergenic compounds in nettle are readily absorbed into the body and excreted in the urine when a nettle extract is delivered orally as a lozenge. In addition, DART TOF-MS is useful in quantifying multiple components in biological matrices with little or no sample preparation.","address":"","school":"","issn":"","doi":"","isi":"","pubmed":"","key":"Ayers2008","howpublished":" http:\/\/users.comcen.com.au\/~journals\/urticaprint2009.pdf","urllink":" http:\/\/users.comcen.com.au\/~journals\/urticaprint2009.pdf","refid":291,"weight":291}
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{userid:"p_v", "articletype":"article","pages":"6-21","author":"S Ayers, B Jr Roschek, J M Williams, R S Alberte","year":"2008","title":"","month":"","journal":"","publisher":"","volume":"5","number":"","note":"","tags":"AccuTOF","booktitle":"","editor":"","abstract":"Pharmacokinetic analyses were conducted using DART TOF-MS on the uptake of bioactive components present in a nettle (Urtica dioica) extract delivered orally as a lozenge. Previously adenine, synephrine, osthole, and nicotinamide were shown to be key bioactives contributing to the anti-inflammatory and anti-allergy properties of the nettle extract (Roschek et al, 2009). Average serum concentrations of adenine reached 35.2 nmol L-1, nicotinamide reached 8.7 nmol L-1, osthole reached 11.0 nmol L-1, and synephrine reached 107.4 nmol L-1. These serum levels are equivalent to 0.3%, 0.2%, 0.2%, and 1.6% oral bioavailability for adenine, synephrine, osthole and nicotinamide respectively. Urine concentrations for adenine, nicotinamide, synephrine, and osthole reached 4.9 nmol L-1, 2.5 nmol L-1, 6.6 nmol L-1, and 0.2 nmol L-1, respectively. The major pharmacokinetic parameters (Cmax, Tmax, T1\/2) were determined and compared for serum and urine. For all three of the compounds, Cmax values decreased 2- to 16-fold in urine compared to serum, Tmax values increased 2- to 12-fold, and T1\/2 values increased 2- to 10-fold. Molecular modeling revealed that these compounds were not likely to cross the blood-brain barrier, particularly important for the anti-histamine bioactives to ensure a non-drowsy activity. These results show that antiinflammatory and anti-allergenic compounds in nettle are readily absorbed into the body and excreted in the urine when a nettle extract is delivered orally as a lozenge. In addition, DART TOF-MS is useful in quantifying multiple components in biological matrices with little or no sample preparation.","address":"","school":"","issn":"","doi":"","isi":"","pubmed":"","key":"Ayers2008","howpublished":" http:\/\/users.comcen.com.au\/~journals\/urticaprint2009.pdf","urllink":" http:\/\/users.comcen.com.au\/~journals\/urticaprint2009.pdf","refid":1228,"weight":1228}
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{userid:"p_v", "articletype":"article","pages":"6-21","author":"S Ayers, B Jr Roschek, J M Williams, R S Alberte","year":"2008","title":"","month":"","journal":"","publisher":"","volume":"5","number":"","note":"","tags":"AccuTOF","booktitle":"","editor":"","abstract":"Pharmacokinetic analyses were conducted using DART TOF-MS on the uptake of bioactive components present in a nettle (Urtica dioica) extract delivered orally as a lozenge. Previously adenine, synephrine, osthole, and nicotinamide were shown to be key bioactives contributing to the anti-inflammatory and anti-allergy properties of the nettle extract (Roschek et al, 2009). Average serum concentrations of adenine reached 35.2 nmol L-1, nicotinamide reached 8.7 nmol L-1, osthole reached 11.0 nmol L-1, and synephrine reached 107.4 nmol L-1. These serum levels are equivalent to 0.3%, 0.2%, 0.2%, and 1.6% oral bioavailability for adenine, synephrine, osthole and nicotinamide respectively. Urine concentrations for adenine, nicotinamide, synephrine, and osthole reached 4.9 nmol L-1, 2.5 nmol L-1, 6.6 nmol L-1, and 0.2 nmol L-1, respectively. The major pharmacokinetic parameters (Cmax, Tmax, T1\/2) were determined and compared for serum and urine. For all three of the compounds, Cmax values decreased 2- to 16-fold in urine compared to serum, Tmax values increased 2- to 12-fold, and T1\/2 values increased 2- to 10-fold. Molecular modeling revealed that these compounds were not likely to cross the blood-brain barrier, particularly important for the anti-histamine bioactives to ensure a non-drowsy activity. These results show that antiinflammatory and anti-allergenic compounds in nettle are readily absorbed into the body and excreted in the urine when a nettle extract is delivered orally as a lozenge. In addition, DART TOF-MS is useful in quantifying multiple components in biological matrices with little or no sample preparation.","address":"","school":"","issn":"","doi":"","isi":"","pubmed":"","key":"Ayers2008","howpublished":" http:\/\/users.comcen.com.au\/~journals\/urticaprint2009.pdf","urllink":" http:\/\/users.comcen.com.au\/~journals\/urticaprint2009.pdf","refid":2161,"weight":2161}
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{userid:"svdstarget_pub", "refid":"32","repocollections":"","attachment":"","_thumb":"","articletype":"article","sectionheading":"","title":"Circulating Monocyte Chemoattractant Protein-1 and Risk of Stroke: Meta-Analysis of Population-Based Studies Involving 17\u2009180 Individuals.","year":"2019","author":"Marios K Georgakis, Rainer Malik, Harry Bj\u00f6rkbacka, Tiberiu Alexandru Pana, Serkalem Demissie, Colby Ayers, Mohamed A Elhadad, Myriam Fornage, Alexa S Beiser, Emelia J Benjamin, S Matthijs Boekholdt, Gunnar Engstr\u00f6m, Christian Herder, Ron C Hoogeveen, Wolfgang Koenig, Olle Melander, Marju Orho-Melander, Alexandru Schiopu, Martin S\u00f6derholm, Nick Wareham, Christie M Ballantyne, Annette Peters, Sudha Seshadri, Phyo K Myint, Jan Nilsson, James A de Lemos, Martin Dichgans","journal":"Circulation research","volume":"125","number":"8","pages":"773-782","month":"09","doi":"10.1161\/CIRCRESAHA.119.315380","pubmed":"31476962","pdflink":"","urllink":"","abstract":"Proinflammatory cytokines have been identified as potential targets for lowering vascular risk. Experimental evidence and Mendelian randomization suggest a role of MCP-1 (monocyte chemoattractant protein-1) in atherosclerosis and stroke. However, data from large-scale observational studies are lacking.  To determine whether circulating levels of MCP-1 are associated with risk of incident stroke in the general population.  We used previously unpublished data on 17\u2009180 stroke-free individuals (mean age, 56.7\u00b18.1 years; 48.8% men) from 6 population-based prospective cohort studies and explored associations between baseline circulating MCP-1 levels and risk of any stroke, ischemic stroke, and hemorrhagic stroke during a mean follow-up interval of 16.3 years (280\u2009522 person-years at risk; 1435 incident stroke events). We applied Cox proportional-hazards models and pooled hazard ratios (HRs) using random-effects meta-analyses. After adjustments for age, sex, race, and vascular risk factors, higher MCP-1 levels were associated with increased risk of any stroke (HR per 1-SD increment in ln-transformed MCP-1, 1.07; 95% CI, 1.01-1.14). Focusing on stroke subtypes, we found a significant association between baseline MCP-1 levels and higher risk of ischemic stroke (HR, 1.11 [1.02-1.21]) but not hemorrhagic stroke (HR, 1.02 [0.82-1.29]). The results followed a dose-response pattern with a higher risk of ischemic stroke among individuals in the upper quartiles of MCP-1 levels as compared with the first quartile (HRs, second quartile: 1.19 [1.00-1.42]; third quartile: 1.35 [1.14-1.59]; fourth quartile: 1.38 [1.07-1.77]). There was no indication for heterogeneity across studies, and in a subsample of 4 studies (12\u2009516 individuals), the risk estimates were stable after additional adjustments for circulating levels of IL (interleukin)-6 and high-sensitivity CRP (C-reactive protein).  Higher circulating levels of MCP-1 are associated with increased long-term risk of stroke. Our findings along with genetic and experimental evidence suggest that MCP-1 signaling might represent a therapeutic target to lower stroke risk.Visual Overview: An online visual overview is available for this article.","note":"","tags":"Adult,Aged,Atherosclerosis,Biomarkers,Chemokine CCL2,Female,Humans,Male,Middle Aged,Stroke","weight":32,"publisher":"","booktitle":"","editor":"","address":"","school":"","issn":"1524-4571","isi":"","key":"Georgakis2019","howpublished":""}
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{userid:"costream_pub", "refid":"17","repocollections":"","attachment":"","_thumb":"","articletype":"article","sectionheading":"","title":"Circulating Monocyte Chemoattractant Protein-1 and Risk of Stroke: Meta-Analysis of Population-Based Studies Involving 17\u2009180 Individuals.","year":"2019","author":"Marios K Georgakis, Rainer Malik, Harry Bj\u00f6rkbacka, Tiberiu Alexandru Pana, Serkalem Demissie, Colby Ayers, Mohamed A Elhadad, Myriam Fornage, Alexa S Beiser, Emelia J Benjamin, S Matthijs Boekholdt, Gunnar Engstr\u00f6m, Christian Herder, Ron C Hoogeveen, Wolfgang Koenig, Olle Melander, Marju Orho-Melander, Alexandru Schiopu, Martin S\u00f6derholm, Nick Wareham, Christie M Ballantyne, Annette Peters, Sudha Seshadri, Phyo K Myint, Jan Nilsson, James A de Lemos, Martin Dichgans","journal":"Circulation research","volume":"125","number":"8","pages":"773-782","month":"09","doi":"10.1161\/CIRCRESAHA.119.315380","pubmed":"31476962","pdflink":"","urllink":"","abstract":"Proinflammatory cytokines have been identified as potential targets for lowering vascular risk. Experimental evidence and Mendelian randomization suggest a role of MCP-1 (monocyte chemoattractant protein-1) in atherosclerosis and stroke. However, data from large-scale observational studies are lacking.  To determine whether circulating levels of MCP-1 are associated with risk of incident stroke in the general population.  We used previously unpublished data on 17\u2009180 stroke-free individuals (mean age, 56.7\u00b18.1 years; 48.8% men) from 6 population-based prospective cohort studies and explored associations between baseline circulating MCP-1 levels and risk of any stroke, ischemic stroke, and hemorrhagic stroke during a mean follow-up interval of 16.3 years (280\u2009522 person-years at risk; 1435 incident stroke events). We applied Cox proportional-hazards models and pooled hazard ratios (HRs) using random-effects meta-analyses. After adjustments for age, sex, race, and vascular risk factors, higher MCP-1 levels were associated with increased risk of any stroke (HR per 1-SD increment in ln-transformed MCP-1, 1.07; 95% CI, 1.01-1.14). Focusing on stroke subtypes, we found a significant association between baseline MCP-1 levels and higher risk of ischemic stroke (HR, 1.11 [1.02-1.21]) but not hemorrhagic stroke (HR, 1.02 [0.82-1.29]). The results followed a dose-response pattern with a higher risk of ischemic stroke among individuals in the upper quartiles of MCP-1 levels as compared with the first quartile (HRs, second quartile: 1.19 [1.00-1.42]; third quartile: 1.35 [1.14-1.59]; fourth quartile: 1.38 [1.07-1.77]). There was no indication for heterogeneity across studies, and in a subsample of 4 studies (12\u2009516 individuals), the risk estimates were stable after additional adjustments for circulating levels of IL (interleukin)-6 and high-sensitivity CRP (C-reactive protein).  Higher circulating levels of MCP-1 are associated with increased long-term risk of stroke. Our findings along with genetic and experimental evidence suggest that MCP-1 signaling might represent a therapeutic target to lower stroke risk.Visual Overview: An online visual overview is available for this article.","note":"","tags":"Adult,Aged,Atherosclerosis,Biomarkers,Chemokine CCL2,Female,Humans,Male,Middle Aged,Stroke","weight":17,"publisher":"","booktitle":"","editor":"","address":"","school":"","issn":"1524-4571","isi":"","key":"Georgakis2019","howpublished":""}
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