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{userid:"berger", "refid":"137","repocollections":"","attachment":"","_thumb":"","articletype":"article","sectionheading":"","title":"Real time variable rate spraying based on 3D visual inputs","year":"2024","author":"Berger, L. T., Perales, P., Alarc\u00f3n, J.","journal":"Aspects of Applied Biology","volume":"","number":"148","pages":"81 - 88","month":"January","doi":"https:\/\/doi.org\/10.5281\/zenodo.10611187","pubmed":"","pdflink":"https:\/\/zenodo.org\/records\/10611187\/files\/pub_2024_Real%20time%20variable%20rate%20spraying_AAB.pdf?download=1","urllink":"https:\/\/zenodo.org\/records\/10611187","abstract":"","note":"","tags":"","weight":137,"booktitle":"Aspects of Applied Biology 148, International Advances in Pesticide Application,  pp.","editor":"","organization":"","address":"Brighton, UK","publisher":"Association of Applied Biologists (AAB)"}
,

{userid:"berger", "refid":134,"repocollections":"","attachment":"","_thumb":"","articletype":"inproceedings","sectionheading":"","title":"3D Computer Vision for Real Time Sprayer Adjustments","year":"2023","author":"Berger, L. T., Alarc\u00f3n, J., Perales, P., Ukhandeeva, E. ","booktitle":"16th Workshop on Spray Application and Precision Technology in Fruit Growing (SUPROFRUIT)","editor":"","pages":"","organization":"","address":"","publisher":"Suprofruit Scientific Comittee","doi":"","pubmed":"","pdflink":"https:\/\/zenodo.org\/records\/10000559\/files\/Suprofruit%20Final%20abstract%20submission_LIFEAIs_for_Zenodo_v11.pdf?download=1","urllink":"https:\/\/zenodo.org\/records\/10000559","abstract":"","note":"","tags":"","weight":134}
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{userid:"sctr", "articletype":"article","pages":"463-468","author":"Timothy B Niewold, Jennifer A Kelly, Silvia N Kariuki, Beverly S Franek, Akaash A Kumar, Kenneth M Kaufman, Kenaz Thomas, Daniel Walker, Stan Kamp, Jacqueline M Frost, Andrew K Wong, Joan T Merrill, Marta E Alarc\u00f3n-Riquelme, Mohammed Tikly, Rosalind Ramsey-Goldman, John D Reveille, Michelle A Petri, Jeffrey C Edberg, Robert P Kimberly, Graciela S Alarc\u00f3n, Diane L Kamen, Gary S Gilkeson, Timothy J Vyse, Judith A James, Patrick M Gaffney, Kathy L Moser, Mary K Crow, John B Harley","year":"2012","title":"IRF5 haplotypes demonstrate diverse serological associations which predict serum interferon alpha activity and explain the majority of the genetic association with systemic lupus erythematosus.","month":"Mar","journal":"Annals of the rheumatic diseases","publisher":"","volume":"71","number":"3","note":"","tags":"African Americans,Antibodies, Antinuclear,Autoantibodies,Case-Control Studies,DNA,European Continental Ancestry Group,Genetic Predisposition to Disease,Genotype,Haplotypes,Humans,Interferon Regulatory Factors,Interferon-alpha,Lupus Erythematosus, Systemic,Polymorphism, Single Nucleotide","booktitle":"","editor":"","abstract":"High serum interferon \u03b1 (IFN\u03b1) activity is a heritable risk factor for systemic lupus erythematosus (SLE). Auto-antibodies found in SLE form immune complexes which can stimulate IFN\u03b1 production by activating endosomal Toll-like receptors and interferon regulatory factors (IRFs), including IRF5. Genetic variation in IRF5 is associated with SLE susceptibility; however, it is unclear how IRF5 functional genetic elements contribute to human disease.","address":"","school":"","issn":"1468-2060","doi":"10.1136\/annrheumdis-2011-200463","isi":"","pubmed":"22088620","key":"Niewold2012","howpublished":"","urllink":"","refid":326,"weight":326}
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{userid:"marc.buyse", "articletype":"article","pages":"647-649","author":"J Bartholeyns, J L Romet-Lemonne, M Chokri, M Buyse, T Velu, C Bruyns, J J Van de Winkel, J Heeney, G Koopman, M Malmsten, D De Groote, M Monsigny, P Midoux, B Alarcon","year":"1998","title":"Cellular vaccines.","month":"Sep\/Oct","journal":"Res Immunol","publisher":"","volume":"149","number":"7-8","note":"","tags":"Animals,Antigen-Presenting Cells,Cancer Vaccines,Clinical Trials as Topic,Genetic Vectors,Humans,Male,Melanoma,Monocytes,Prostatic Neoplasms,T-Lymphocytes","booktitle":"","editor":"","abstract":"This project is devoted to the development of novel cellular vaccines designed to treat cancer patients. These cellular vaccines present and enhance immunogens, which will elicit a potent immune response. The goal is to achieve safe and effective immune reaction against the patient's own tumour. (1) Autologous cellular vaccines are prepared by processing circulating blood mononuclear cells outside of the patient's body (ex vivo) to differentiate them into antigen-presenting cells (APCs). Monocyte-derived APCs (MD-APCs) are then grown in the presence of exogenous target antigens (tumour cell debris, or apoptotic bodies) to become fully mature APCs. (2) Functionality for antigen presentation to T cells of ex vivo MD-APCs is evaluated in vivo. (3) Cellular vaccines are tested in selected rodent animal models. Efficiency and immune response are monitored in pertinent experimental systems for cancer. Pharmacological data are generated for clinical investigation. Tolerance and biologic effects are documented in primates. (4) The first clinical trials on cancer patients are taking place in 1998 on melanoma and prostate cancer to validate the concept. Specialized cell processors with dedicated software and standardized controls are being developed and used for the preparation of cellular vaccines. (5) The evaluation of new non-viral vectors and the validation of new non-viral transfection methods of mononuclear cells with marker genes is in progress and will lead to the ex vivo transfection of genes coding for immunostimulating cytokines or for tumour antigens in MD-APCs. Efficiency will be validated in vitro and in animal models. The ex vivo and animal model studies validate the clinical relevance of this new cellular immunotechnology. Clinical validation of individual autologous cellular vaccines in specific indications for which no treatment is presently available will allow the development of cellular and gene immunotherapy for other types of cancers.","address":"","school":"","issn":"0923-2494","doi":"","isi":"","pubmed":"9851517","key":"Bartholeyns1998","howpublished":"","urllink":"","refid":85}
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{userid:"sctr", "articletype":"article","pages":"842-849","author":"Paula S Ramos, James C Oates, Diane L Kamen, Adrienne H Williams, Patrick M Gaffney, Jennifer A Kelly, Kenneth M Kaufman, Robert P Kimberly, Timothy B Niewold, Chaim O Jacob, Betty P Tsao, Graciela S Alarc\u00f3n, Elizabeth E Brown, Jeffrey C Edberg, Michelle A Petri, Rosalind Ramsey-Goldman, John D Reveille, Luis M Vil\u00e1, Judith A James, Joel M Guthridge, Joan T Merrill, Susan A Boackle, Barry I Freedman, R Hal Scofield, Anne M Stevens, Timothy J Vyse, Lindsey A Criswell, Kathy L Moser, Marta E Alarc\u00f3n-Riquelme, Carl D Langefeld, John B Harley, Gary S Gilkeson","year":"2013","title":"Variable association of reactive intermediate genes with systemic lupus erythematosus in populations with different African ancestry.","month":"Jun","journal":"The Journal of rheumatology","publisher":"","volume":"40","number":"6","note":"","tags":"Adult,African Continental Ancestry Group,Alleles,Genetic Association Studies,Genetic Loci,Genetic Predisposition to Disease,Genotype,Glutathione Reductase,Haplotypes,Humans,Lupus Erythematosus, Systemic,NADH Dehydrogenase,Nitric Oxide Synthase Type I,Polymorphism, Single Nucleotide","booktitle":"","editor":"","abstract":"Little is known about the genetic etiology of systemic lupus erythematosus (SLE) in individuals of African ancestry, despite its higher prevalence and greater disease severity. Overproduction of nitric oxide (NO) and reactive oxygen species are implicated in the pathogenesis and severity of SLE, making NO synthases and other reactive intermediate-related genes biological candidates for disease susceptibility. We analyzed variation in reactive intermediate genes for association with SLE in 2 populations with African ancestry.","address":"","school":"","issn":"0315-162X","doi":"10.3899\/jrheum.120989","isi":"","pubmed":"23637325","key":"Ramos2013","howpublished":"","urllink":"","refid":233,"weight":233}
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{userid:"sctr", "articletype":"article","pages":"1960-1969","author":"Bahram Namjou, Chan-Bum Choi, Isaac T W Harley, Marta E Alarc\u00f3n-Riquelme,  , Jennifer A Kelly, Stuart B Glenn, Joshua O Ojwang, Adam Adler, Kwangwoo Kim, Caroline J Gallant, Susan A Boackle, Lindsey A Criswell, Robert P Kimberly, Elizabeth E Brown, Jeffrey Edberg, Graciela S Alarc\u00f3n, Anne M Stevens, Chaim O Jacob, Gary S Gilkeson, Diane L Kamen, Betty P Tsao, Juan-Manuel Anaya, Eun-Mi Kim, So-Yeon Park, Yoon-Kyoung Sung, Joel M Guthridge, Joan T Merrill, Michelle Petri, Rosalind Ramsey-Goldman, Luis M Vil\u00e1, Timothy B Niewold, Javier Martin, Bernardo A Pons-Estel,  , Timothy J Vyse, Barry I Freedman, Kathy L Moser, Patrick M Gaffney, Adrienne H Williams, Mary E Comeau, John D Reveille, Changwon Kang, Judith A James, R Hal Scofield, Carl D Langefeld, Kenneth M Kaufman, John B Harley, Sang-Cheol Bae","year":"2012","title":"Evaluation of TRAF6 in a large multiancestral lupus cohort.","month":"Jun","journal":"Arthritis and rheumatism","publisher":"","volume":"64","number":"6","note":"","tags":"Alleles,Case-Control Studies,Cohort Studies,Female,Gene Frequency,Genetic Association Studies,Genetic Predisposition to Disease,Genotype,Haplotypes,Humans,Lupus Erythematosus, Systemic,Male,Polymorphism, Single Nucleotide,TNF Receptor-Associated Factor 6","booktitle":"","editor":"","abstract":"Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease with significant immune system aberrations resulting from complex heritable genetics as well as environmental factors. We undertook to study the role of TRAF6 as a candidate gene for SLE, since it plays a major role in several signaling pathways that are important for immunity and organ development.","address":"","school":"","issn":"1529-0131","doi":"10.1002\/art.34361","isi":"","pubmed":"22231568","key":"Namjou2012","howpublished":"","urllink":"","refid":316,"weight":316}
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{userid:"michael.bussmann", "refid":"98","repocollections":"","attachment":"","_thumb":"","articletype":"inproceedings","sectionheading":"","title":"Laser cooling of stored relativistic ion beams with large momentum spreads using a laser system with a wide scanning range","year":"2014","author":"W Wen, D Winters, T Beck, B Rein, Th Walther, S Tichelmann, G Birkl, R Sanchez-Alarcon, J Ullmann, M Lochmann, W N\u00f6rtersh\u00e4user, C Clark, C Kozhuharov, Th K\u00fchl, S Sanjari, Y Litvinov, T Giacomini, M Steck, C Dimopoulou, F Nolden, Th St\u00f6hlker, J Yang, D Zhang, X Ma, M Seltmann, M Siebold, U Schramm, M Bussmann","booktitle":"XXVIII International Conference on Photonic, Electronic and Atomic Collisions ICPEAC 2013","editor":"Guoqing Xiao, Xiaohong Cai, Dajun Ding, Xinwen Ma, Yongtao Zhao","pages":"122005","organization":"Institute of Modern Physics, Chinese Academy of Science","address":"509 Nanchang Road, Lanzhou 730000, Gansu Province, P. R. China ","publisher":"IOP Publishing","doi":"10.1088\/1742-6596\/488\/12\/122005","pubmed":"","pdflink":"http:\/\/iopscience.iop.org\/1742-6596\/488\/12\/122005\/pdf\/1742-6596_488_12_122005.pdf","urllink":"http:\/\/stacks.iop.org\/1742-6596\/488\/i=12\/a=122005","abstract":"New results on laser cooling of stored, bunched, relativistic ion beams are presented. For the first time it has been possible to cool an ion beam with large momentum spread without initial electron cooling or scanning of the bunching frequency by using a single cw laser system.","note":"","tags":"laser cooling, ion beam, storage ring, broadband, scanning, large momenbtum spread","weight":98,"journal":"Journal of Physics : Conference Series","volume":"488","number":"12","month":"April","school":"","issn":"","isi":"","key":"ref1742-6596-488-12-122005","howpublished":"http:\/\/stacks.iop.org\/1742-6596\/488\/i=12\/a=122005"}
,

{userid:"sctr", "articletype":"article","pages":"1809-1814","author":"Kwangwoo Kim, Elizabeth E Brown, Chan-Bum Choi, Marta E Alarc\u00f3n-Riquelme,  , Jennifer A Kelly, Stuart B Glenn, Joshua O Ojwang, Adam Adler, Hye-Soon Lee, Susan A Boackle, Lindsey A Criswell, Graciela S Alarc\u00f3n, Jeffrey C Edberg, Anne M Stevens, Chaim O Jacob, Gary S Gilkeson, Diane L Kamen, Betty P Tsao, Juan-Manuel Anaya, Joel M Guthridge, Swapan K Nath, Bruce Richardson, Amr H Sawalha, Young Mo Kang, Seung Cheol Shim, Chang-Hee Suh, Soo-Kon Lee, Chang-sik Kim, Joan T Merrill, Michelle Petri, Rosalind Ramsey-Goldman, Luis M Vil\u00e1, Timothy B Niewold, Javier Martin, Bernardo A Pons-Estel,  , Timothy J Vyse, Barry I Freedman, Kathy L Moser, Patrick M Gaffney, Adrienne Williams, Mary Comeau, John D Reveille, Judith A James, R Hal Scofield, Carl D Langefeld, Kenneth M Kaufman, John B Harley, Changwon Kang, Robert P Kimberly, Sang-Cheol Bae","year":"2012","title":"Variation in the ICAM1-ICAM4-ICAM5 locus is associated with systemic lupus erythematosus susceptibility in multiple ancestries.","month":"Nov","journal":"Annals of the rheumatic diseases","publisher":"","volume":"71","number":"11","note":"","tags":"Cell Adhesion Molecules,Continental Population Groups,Genetic Markers,Genetic Predisposition to Disease,Genetics, Population,Genome-Wide Association Study,Humans,Intercellular Adhesion Molecule-1,Lupus Erythematosus, Systemic,Nerve Tissue Proteins,Polymorphism, Single Nucleotide","booktitle":"","editor":"","abstract":"Systemic lupus erythematosus (SLE; OMIM 152700) is a chronic autoimmune disease for which the aetiology includes genetic and environmental factors. ITGAM, integrin \u03b1(M) (complement component 3 receptor 3 subunit) encoding a ligand for intracellular adhesion molecule (ICAM) proteins, is an established SLE susceptibility locus. This study aimed to evaluate the independent and joint effects of genetic variations in the genes that encode ITGAM and ICAM.","address":"","school":"","issn":"1468-2060","doi":"10.1136\/annrheumdis-2011-201110","isi":"","pubmed":"22523428","key":"Kim2012","howpublished":"","urllink":"","refid":290,"weight":290}
,

{userid:"sctr", "articletype":"article","pages":"380-387","author":"S Wang, I Adrianto, G B Wiley, C J Lessard, J A Kelly, A J Adler, S B Glenn, A H Williams, J T Ziegler, M E Comeau, M C Marion, B E Wakeland, C Liang, K M Kaufman, J M Guthridge, M E Alarc\u00f3n-Riquelme,  , G S Alarc\u00f3n, J-M Anaya, S-C Bae, J-H Kim, Y B Joo, S A Boackle, E E Brown, M A Petri, R Ramsey-Goldman, J D Reveille, L M Vil\u00e1, L A Criswell, J C Edberg, B I Freedman, G S Gilkeson, C O Jacob, J A James, D L Kamen, R P Kimberly, J Martin, J T Merrill, T B Niewold, B A Pons-Estel, R H Scofield, A M Stevens, B P Tsao, T J Vyse, C D Langefeld, J B Harley, E K Wakeland, K L Moser, C G Montgomery, P M Gaffney","year":"2012","title":"A functional haplotype of UBE2L3 confers risk for systemic lupus erythematosus.","month":"Jul","journal":"Genes and immunity","publisher":"","volume":"13","number":"5","note":"","tags":"African Americans,Alleles,Asian Continental Ancestry Group,European Continental Ancestry Group,Female,Genetic Predisposition to Disease,Haplotypes,Hispanic Americans,Humans,Linkage Disequilibrium,Lupus Erythematosus, Systemic,Male,Polymorphism, Single Nucleotide,Ubiquitin-Conjugating Enzymes","booktitle":"","editor":"","abstract":"Systemic lupus erythematosus (SLE) is an autoimmune disease with diverse clinical manifestations characterized by the development of pathogenic autoantibodies manifesting in inflammation of target organs such as the kidneys, skin and joints. Genome-wide association studies have identified genetic variants in the UBE2L3 region that are associated with SLE in subjects of European and Asian ancestry. UBE2L3 encodes an ubiquitin-conjugating enzyme, UBCH7, involved in cell proliferation and immune function. In this study, we sought to further characterize the genetic association in the region of UBE2L3 and use molecular methods to determine the functional effect of the risk haplotype. We identified significant associations between variants in the region of UBE2L3 and SLE in individuals of European and Asian ancestry that exceeded a Bonferroni-corrected threshold (P<1 \u00d7 10(-4)). A single risk haplotype was observed in all associated populations. Individuals harboring the risk haplotype display a significant increase in both UBE2L3 mRNA expression (P=0.0004) and UBCH7 protein expression (P=0.0068). The results suggest that variants carried on the SLE-associated UBE2L3 risk haplotype influence autoimmunity by modulating UBCH7 expression.","address":"","school":"","issn":"1476-5470","doi":"10.1038\/gene.2012.6","isi":"","pubmed":"22476155","key":"Wang2012","howpublished":"","urllink":"","refid":298,"weight":298}
,

{userid:"sctr", "articletype":"article","pages":"648-660","author":"Christopher J Lessard, Indra Adrianto, John A Ice, Graham B Wiley, Jennifer A Kelly, Stuart B Glenn, Adam J Adler, He Li, Astrid Rasmussen, Adrienne H Williams, Julie Ziegler, Mary E Comeau, Miranda Marion, Benjamin E Wakeland, Chaoying Liang, Paula S Ramos, Kiely M Grundahl, Caroline J Gallant, Marta E Alarc\u00f3n-Riquelme, Graciela S Alarc\u00f3n, Juan-Manuel Anaya, Sang-Cheol Bae, Susan A Boackle, Elizabeth E Brown, Deh-Ming Chang, Soo-Kyung Cho, Lindsey A Criswell, Jeffrey C Edberg, Barry I Freedman, Gary S Gilkeson, Chaim O Jacob, Judith A James, Diane L Kamen, Robert P Kimberly, Jae-Hoon Kim, Javier Martin, Joan T Merrill, Timothy B Niewold, So-Yeon Park, Michelle A Petri, Bernardo A Pons-Estel, Rosalind Ramsey-Goldman, John D Reveille, R Hal Scofield, Yeong Wook Song, Anne M Stevens, Betty P Tsao, Luis M Vila, Timothy J Vyse, Chack-Yung Yu, Joel M Guthridge, Kenneth M Kaufman, John B Harley, Edward K Wakeland, Carl D Langefeld, Patrick M Gaffney, Courtney G Montgomery, Kathy L Moser,  ,  ","year":"2012","title":"Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as susceptibility loci for systemic lupus erythematosus in a large-scale multiracial replication study.","month":"Apr","journal":"American journal of human genetics","publisher":"","volume":"90","number":"4","note":"","tags":"African Continental Ancestry Group,Asian Continental Ancestry Group,Chromosome Mapping,Egg Proteins,European Continental Ancestry Group,Female,Genetic Predisposition to Disease,Haplotypes,Hispanic Americans,Humans,Ikaros Transcription Factor,Indians, North American,Interferon Regulatory Factors,Lupus Erythematosus, Systemic,Male,Membrane Proteins,Polymorphism, Single Nucleotide,Sequence Analysis, DNA","booktitle":"","editor":"","abstract":"Systemic lupus erythematosus (SLE) is a chronic heterogeneous autoimmune disorder characterized by the loss of tolerance to self-antigens and dysregulated interferon responses. The etiology of SLE is complex, involving both heritable and environmental factors. Candidate-gene studies and genome-wide association (GWA) scans have been successful in identifying new loci that contribute to disease susceptibility; however, much of the heritable risk has yet to be identified. In this study, we sought to replicate 1,580 variants showing suggestive association with SLE in a previously published GWA scan of European Americans; we tested\u00a0a multiethnic population consisting of 7,998 SLE cases and 7,492 controls of European, African American, Asian, Hispanic, Gullah, and Amerindian ancestry to find association with the disease. Several genes relevant to immunological pathways showed association with SLE. Three loci\u00a0exceeded the genome-wide significance threshold: interferon regulatory factor 8 (IRF8; rs11644034; p(meta-Euro) = 2.08\u00a0\u00d7 10(-10)), transmembrane protein 39A (TMEM39A; rs1132200; p(meta-all) = 8.62\u00a0\u00d7 10(-9)), and 17q21 (rs1453560; p(meta-all) = 3.48\u00a0\u00d7 10(-10)) between\u00a0IKAROS family of zinc finger 3 (AIOLOS; IKZF3) and zona pellucida binding protein 2 (ZPBP2). Fine mapping, resequencing, imputation, and haplotype analysis of IRF8 indicated that three independent effects tagged by rs8046526, rs450443, and rs4843869, respectively, were required for risk in individuals of European ancestry. Eleven additional replicated effects (5\u00a0\u00d7 10(-8) < p(meta-Euro) < 9.99\u00a0\u00d7 10(-5)) were observed with CFHR1, CADM2, LOC730109\/IL12A, LPP, LOC63920, SLU7, ADAMTSL1, C10orf64, OR8D4, FAM19A2, and STXBP6. The results of this study increase the number of confirmed SLE risk loci and identify others warranting further investigation.","address":"","school":"","issn":"1537-6605","doi":"10.1016\/j.ajhg.2012.02.023","isi":"","pubmed":"22464253","key":"Lessard2012","howpublished":"","urllink":"","refid":300,"weight":300}
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