// +author:y andachi +author:andachi 
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{userid:"thomas.burglin", "articletype":"article","pages":"587-597","author":"G Cassata, H Kagoshima, Y Andachi, Y Kohara, M B D\u00fcrrenberger, D H Hall, T R B\u00fcrglin","year":"2000","title":"The LIM homeobox gene ceh-14 confers thermosensory function to the AFD neurons in Caenorhabditis elegans.","month":"Mar","journal":"Neuron","publisher":"","volume":"25","number":"3","note":"","tags":"Amino Acid Sequence,Animals,Animals, Genetically Modified,Behavior, Animal,Body Temperature Regulation,Caenorhabditis elegans,Caenorhabditis elegans Proteins,Gene Deletion,Gene Expression,Homeodomain Proteins,Hot Temperature,Interneurons,Molecular Sequence Data,Motor Neurons,Movement,Mutagenesis,Neurons, Afferent,Neuropeptides","booktitle":"","editor":"","abstract":"In Caenorhabditis elegans three pairs of neurons, AFD, AIY, and AIZ, play a key role in thermosensation. The LIM homeobox gene ceh-14 is expressed in the AFD thermosensory neurons. ceh-14 mutant animals display athermotactic behaviors, although the neurons are still present and differentiated. Two other LIM homeobox genes, ttx-3 and lin-11, function in the two interneurons AIY and AIZ, respectively. Thus, the three key thermosensory neurons are specified by three different LIM homeobox genes. ceh-14 ttx-3 lin-11 triple mutant animals have a basic cryophilic thermotaxis behavior indicative of a second thermotaxis pathway. Misexpression of ceh-14 in chemosensory neurons can restore thermotactic behavior without impairing the chemosensory function. Thus, ceh-14 confers thermosensory function to neurons.","address":"","school":"","issn":"0896-6273","doi":"","isi":"","pubmed":"10774727","key":"Cassata2000","howpublished":"","urllink":"","refid":29}
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