Vellarkad N Viswanadhan

Vellarkad N Viswanadhan, Rajesh Hariharan, Vitukudi N Balaji (2011) Atom type preferences, structural diversity, and property profiles of known drugs, leads and non-drugs: A comparative assessment ACS Comb. Sci 13: 327-336

Abstract: A new characterization of known drug, lead, and representative nondrug databases was performed taking into account several properties at the atomic and molecular levels. This characterization included atom type preferences, intrinsic structural diversity (Atom Type Diversity, ATD), and other well-known physicochemical properties, as an approach for rapid assessment of druglikeness for small molecule libraries. To characterize ATD, an elaborate united atom classification, UALOGP (United Atom Log P), with 148 atom types, was developed along with associated atomic physicochemical parameters. This classification also enabled an analysis of atom type and physicochemical property distributions (for calculated log P, molar refractivity, molecular weight, total atom count, and ATD) of drug, lead, and nondrug databases, a reassessment of the Ro5 (Rule of Five) and GVW (GhoseViswanadhan Wendoloski) criteria, and development of new criteria and ranges more accurately reflecting the chemical space occupied by small molecule drugs. A relative druglikeness parameter was defined for atom types in drugs, identifying the most preferred types. The present work demonstrates that drug molecules are constitutionally more diverse relative to nondrugs, while being less diverse than leads.

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Books

2001	(2001) Combinatorial Library Design and Evaluation: Principles, Software Tools and Applications in Drug Discovery Edited by:Arup K. Ghose and Vellarkad N. Viswanadhan. Marcel-Dekker, New York – Basel Abstract: Notes:
Journal articles

2011	Vellarkad N Viswanadhan, Rajesh Hariharan, Vitukudi N Balaji (2011) Atom type preferences, structural diversity, and property profiles of known drugs, leads and non-drugs: A comparative assessment ACS Comb. Sci 13: 327-336 Abstract: A new characterization of known drug, lead, and representative nondrug databases was performed taking into account several properties at the atomic and molecular levels. This characterization included atom type preferences, intrinsic structural diversity (Atom Type Diversity, ATD), and other well-known physicochemical properties, as an approach for rapid assessment of druglikeness for small molecule libraries. To characterize ATD, an elaborate united atom classification, UALOGP (United Atom Log P), with 148 atom types, was developed along with associated atomic physicochemical parameters. This classification also enabled an analysis of atom type and physicochemical property distributions (for calculated log P, molar refractivity, molecular weight, total atom count, and ATD) of drug, lead, and nondrug databases, a reassessment of the Ro5 (Rule of Five) and GVW (GhoseViswanadhan Wendoloski) criteria, and development of new criteria and ranges more accurately reflecting the chemical space occupied by small molecule drugs. A relative druglikeness parameter was defined for atom types in drugs, identifying the most preferred types. The present work demonstrates that drug molecules are constitutionally more diverse relative to nondrugs, while being less diverse than leads. Notes:
	V S Babu, V N Balaji, Vellarkad N Viswanadhan, Ming Fai Chan, Samiron Phukan, Shashidhar N Rao (2011) Three-dimensional pharmacophore modeling studies on antagonists of endothelin receptor ETA Current Science 100: 1847-1855 Abstract: Notes:
2010	Qingping Zeng, Matthew P Bourbeau, G Erich Wohlhieter, Guomin Yao, Holger Monenschein, James T Rider, Matthew R Lee, Shiwen Zhang, Julie Lofgren, Daniel Freeman, Chun Li, Elizabeth Tominey, Xin Huang, Douglas Hoffman, Harvey Yamane, Andrew S Tasker, Celia Dominguez, Vellarkad N Viswanadhan, Randall Hungate, Xiaoling Zhang (2010) 2-Aminothiadiazole Inhibitors of AKT1 as Potential Cancer therapeutics Bioorg. & Med. Chem. Lett 20: 1652-1656 Abstract: Notes:
	Justin K Murray, Chenera Balan, Alan Allgeier, Annie Kasparian, Vellarkad N Viswanadhan, Christopher Wilde, Jennifer R Allen, Sean C Yoder, Gloria Biddlecome, Randall W Hungate, Les P Miranda (2010) Dipeptidyl-quinolone derivatives inhibit hypoxia inducible factor-1a prolyl hydroxylases-1, -2, and -3 with altered selectivity J Combi. Chem. 12: 676-686 Abstract: Notes:
2008	Jian Jeffrey Chen, Wenyuan Qian, Kaustav Biswas, Vellarkad N Viswanadhan, Benny C Askew Stephen Hitchcock, Randall W Hungate, Leyla Arik, Eileen Johnson (2008) Discovery of dihydroquinoxalinone acetamides containing bicyclic amines as potent Bradykinin B1 receptor antagonists Bioorg. & Med. Chem. Lett. 18: 4477-4481 Abstract: Notes:

	Mike Frohn, Vellarkad N Viswanadhan, Alexander J Pickrell, Jennifer E Golden, Kristine M Muller, Roland W Bürli, Gloria Biddlecome, Sean C Yoder, Norma Rogers, Jennifer H Dao, Randall Hungate, Jennifer R Allen (2008) Structure-guided design of substituted aza-benzimidazoles as potent hypoxia inducible factor-1a prolyl hydroxylase-2 inhibitors Bioorg. & Med. Chem. Lett. 18: 5023-5026 Abstract: Notes:
	Christopher M Tegley, Vellarkad N Viswanadhan, Kaustav Biswas, Michael J Frohn, Tanya A N Peterkin, Catherine Chang, Roland W Bürli, Jennifer H Dao, Henrike Veith, Norma Rogers, Sean C Yoder, Gloria Biddlecome, Philip Tagari, R Allen a Jennifer, Randall W Hungate (2008) Discovery of novel hydroxy-thiazoles as HIF-a prolyl hydroxylase inhibitors: SAR, synthesis, and modeling evaluation Bioorg. & Med. Chem. Lett. 18: 4477-4481 Abstract: Notes:
2007	Derin C D’Amico, Toshi Aya, Jason Human, Christopher Fotsch, Jian Jeffery Chen, Kaustav Biswas, Bobby Riahi, Mark H Norman, Christopher A Willoughby, Randall Hungate, Paul J Reider, Gloria Biddlecome, Diana Lester-Zeiner, Carlo Van Stadten, Eileen Johnson, Augustus Kamassah, Leila Arik, Judy Wang, Vellarkad N Viswanadhan, Robert D Groneburg, James Zhan, Hideo Suzuki, Andras Toro, David A Mareska, David E Clark, Darren M Harvey, Lawrence E Burgess, Ellen R Laird, Benny Askew, Gordon Ng (2007) Identification of a Non-peptidic and Conformationally Restricted Bradykinin B1 Receptor Antagonist with Rat Anti-inflammatory Activity J Med Chem 50: 607-610 Abstract: Notes:
	Vellarkad N Viswanadhan, Yaxiong Sun, Mark H Norman (2007) Three Dimensional Quantitative Structure-Activity Relationships (3D-QSARs) and activity predictions of human TRPV1 channel antagonists: Comparative Molecular Field Analysis (CoMFA) and Comparative Molecular Similarity Index Analysis (CoMSIA) of cinnamides J Med Chem 50: 5608-5619 Abstract: Notes:
	Mark H Norman, Jiawang Zhu, Christopher Fotsch, Yunxin Bo, Ning Chen, Partha Chakrabarti, Elizabeth Doherty, Narendar R Gavva, Nobuko Nishimura, Thomas Nixey, Vassil I Ognyanov, Robert M Rzasa, Markian Stec, Sekhar Surapaneni, Rami Tamir, Vellarkad N Viswanadhan, James J S Treanor (2007) Novel Vanilloid Receptor-1 Antagonists: 1. Conformationally Restricted Analogues of trans-cinnamides J Med Chem 50: 3497-3514 Abstract: Notes:
	Robert M Rzasa, Matthew R Kaller, Gang Liu, Ella Magal, Thomas T Nguyen, Timothy D Osslund, David Powers, Vincent J Santora, Vellarkad N Viswanadhan, Hui-Ling Wang, Xiaoling Xiong, Wenge Zhong, Mark H Norman (2007) Structure-Activity Relationships of 3,4-Dihydro-1H-quinazolin-2-one Derivatives as Potential CDK5 Inhibitors Bio-org. & Med. Chem 15: 6574-6595 Abstract: Notes:
2006	Roland W Burli, Han Xu, Xiaoming Zou, Kristine Muller, Jennifer Golden, Michael Frohn, Matthew Adlam, Michele McElvain, Kelly Regal, Vellarkad N Viswanadhan, Philip Tagari, Randall Hungate (2006) Potent hFPRL1 Agonists as Potential Anti-Inflammatory Agents Bio-org. & Med. Chem. Lett 16: 3713-3718 Abstract: Notes:
2005	Narendar R Gavva, L Klionsky, Y Qu, L Shi, Rami Tamir, Steve Edenson, T J Zhang, Vellarkad N Viswanadhan, Attila Toth, Larry V Pearce, Todd W Vanderah, Frank Porreca, Peter M Blumberg, Jack Lile, Yax Sun, Ken Wild, Jean-Claude Louis, James J S Treanor (2005) Molecular Determinants of Vanilloid Sensitivity in TRPV1 J Biol Chem 279: 20283-20295 Abstract: Notes:
2004	Tae-Seong Kim, Andrew B Hague, Tony I Lee, Brian Lian, Chrostopher M Tegley, Xianghong Wang, Teresa L Burgess, Yi-Xin Qian, Sandra Ross, Philip Tagari, Chi-Hwei Lin, Carol Mayeda, Jennifer Dao, Steven Jordan, Christopher Mohr, Janet Cheetham, Vellarkad N Viswanadhan, Andrew S Tasker (2004) (4-Piperidinylphenyl)aminoethyl amides as a novel class of non- covalent cathepsin K inhibitors Bio-org. & Med. Chem. Lett 14: 87-90 Abstract: Notes:
2002	Vellarkad N Viswanadhan, Chenera Balan, Christopher Hulme, Janet C Cheetham, Yaxiong Sun (2002) Knowledge-based Approaches in the Design and Selection of Compound Libraries for Small Molecule Drug Discovery Curr. Opin. in Drug Design and Discovery 5: 400-406 Abstract: Notes:

2001	Arup K Ghose, Vellarkad N Viswanadhan, John J Wendoloski (2001) The Fundamentals of Pharmacophore Modeling in Combinatorial Chemistry Journal of Receptors and Signal Transduction 21: 357-375 Abstract: Notes:
	Vellarkad N Viswanadhan, G A Mueller, S C Basak, J N Weinstein (2001) Comparison of a Neural Net-Based QSAR Algorithm (PCANN) with Hologram- and Multiple Linear Regression-Based QSAR Approaches: Application to 1,4-Dihydropyridine-Based Calcium Channel Antagonists J. Chem. Inf. and Comput. Sci 41: 505-511 Abstract: Notes:
2000	Vellarkad N Viswanadhan, Arup K Ghose, John J Wendoloski (2000) Estimating aqueous solvation and lipophilicity of small organic molecules: A comparative overview of atom/group contribution methods Perspectives in Drug Design and Discovery 19: 85-98 Abstract: Notes:
1999	Arup K Ghose, Vellarkad N Viswanadhan, John J Wendoloski (1999) A Knowledge-Based Approach in Designing Combinatorial or Medicinal Chemistry Libraries for Drug Discovery. 1. A Qualitative and Quantitative Characterization of Known Drug Databases J. Comb. Chem. 1: 55-68 Abstract: Notes:
	Vellarkad N Viswanadhan, Arup K Ghose, U C Singh, John J Wendoloski (1999) Prediction of Solvation Free Energies of Small Organic Molecules: Additive-Constitutive Models Based on Molecular Fingerprints and Atomic Constants J. Chem. Inf. and Comput. Sci. 39: 405-412 Abstract: Notes:
1998	M Rami Reddy, Mark D Erion, Vellarkad N Viswanadhan, D Quentin McDonald, W Clark Still (1998) Solvation Free Energies Derived from the GB/SA Model: Sensitivity of Results on Charge Sets, Protocols and Forcefields J. Comput. Chem, 19: 769-780 Abstract: Notes:
	Arup K Ghose, Vellarkad N Viswanadhan, John J Wendoloski (1998) Prediction of Hydrophobic (lipophilic) properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods J. Phys. Chem 102: 3762-3772 Abstract: Notes:
1997	J N Weinstein, T G Myers, P M O’connor, S H Friend, Fornace, A J Jr, K W Kohn, T Fojo, S E Bates, L V Rubinstein, N L Anderson, J K Buolamwini, W W van osdol, A P Monks, D A Scuderio, E A Sausville, D W Zaharevitz, B Bunow, V N Viswanadhan, G S Johnson, R E Wittes, K D Paull (1997) An Information Intensive Approach to the Molecular Pharmacology of Cancer Science 275: 343-349 Abstract: Notes:
1996	Vellarkad N Viswanadhan, M Rami Reddy, Alexander Wlodawer, M D Varney, John N Weinstein (1996) An Approach to Rapid Estimation of Relative Binding Affinities of Enzyme Inhibitors: Application to Peptidomimetic Inhibitors for the HIV-1 Protease J. Med. Chem. 39: 705-712 Abstract: Notes:
1994	M Rami Reddy, Michael D Varney, Vince Kalish, Vellarkad N Viswanadhan, Krzysztof Appelt (1994) Calculation of Relative Differences in the Binding Free Energies of HIV 1 protease inhibitors: A Thermodynamic-Cycle Perturbation Approach J. Med. Chem. 37: 1145-1152 Abstract: Notes:

	J N Weinstein, T Myers, J Buolamwni, K Raghavan, W van Osdol, J Licht, V N Viswanadhan, K W Kohn, L V Rubinstein, A D Koutsoukos, A Monks, D A Scudiero, N L Anderson, D Zaharevitz, B A Chabner, M R Grever, K D Paull (1994) Predictive Statistics and Artificial Intelligence in the U.S. National Cancer Institute's Drug Discovery Program for Cancer and AIDS Stem Cells 12: 11-17 Abstract: Notes:
1993	Vellarkad N Viswanadhan, M Rami Reddy, Russell J Bacquet, Mark D Erion (1993) An Assessment of Methods for Predicting Lipophilicity: Application to Nucleoside Analogs and Bases J. Comput. Chem. 14: 1019-1026 Abstract: Notes:
1992	John N Weinstein, Kurt W Kohn, Michael R Grever, Vellarkad N Viswanadhan, Lawrence V Rubinstein, Anne P Monks, Dominic A Scudiero, Lester Welch, Antonis D Koutsoukos, August J Chiausa, Kenneth D Paull (1992) Neural Computing in Cancer Drug Development: Predicting Mechanism of Action Science 258: 447-451 Abstract: Notes:
1991	Vellarkad N Viswanadhan, Arup K Ghose, Naeem B Hanna, Steven S Matsumoto, Thomas L Avery, Ganapathi R Revankar, Roland K Robins (1991) Analysis of the Antitumor Activity of Purine-6-Sulfenamide, Sulfinamide and Sulfonamide Nucleosides and Certain Related Compounds Using A Novel Computer Aided Receptor Modeling Procedure J. Med. Chem. 34: 526-532 Abstract: Notes:
	M Rami Reddy, Vellarkad N Viswanadhan, John N Weinstein (1991) Relative Differences in the Binding Free Energies of HIV 1 protease inhibitors: A Thermodynamic-Cycle Perturbation Approach Proc. Natl. Acad. Sci. (USA) 88: 10287-10291 Abstract: Notes:
	Vellarkad N Viswanadhan, Benjamin Denckla, John N Weinstein (1991) A New Joint Prediction Algorithm (Q7-JASEP) Improves the Prediction of Protein Secondary Structure Biochemistry 30: 11164-11172 Abstract: Notes:
1990	Vellarkad N Viswanadhan, Arup K Ghose, Ganapathi R Revankar, Roland K Robins (1990) Estimation of the Atomic Contribution to Octanol-Water Partition Coefficient and Molar Refractivity from Fundamental Atomic and Structural Properties and Their Uses in Computer Aided Drug Design Mathematical and Computer Modeling 14: 505-510 Abstract: Notes:
	Vellarkad N Viswanadhan, Arup K Ghose, John N Weinstein (1990) Mapping the Binding Sites of the Nucleoside Transporter Protein: A 3D-QSAR Study Biochim. Biophys. Acta 1039: 356-366 Abstract: Notes:
	Vellarkad N Viswanadhan, John N Weinstein, Patrick C Elwood (1990) Secondary Structure of the Human Membrane-Associated Folate Binding Protein Using A Joint Prediction Approach J. Biomol. Str. & Dynamics 7: 985-1001 Abstract: Notes:
1989	Arup K Ghose, Vellarkad N Viswanadhan, Yogesh S Sanghvi, L Dee Nord, Randall C Willis, Ganapathi R Revankar, Roland K Robins (1989) Structural Mimicry of Exocyclic Aminoribonucleosides of Certain Substituted Pyrimido[5,4-d]pyrimidines Towards Adenosine Kinase using a Novel Molecular Modeling Procedure Proc. Natl. Acad. Sci. (U. S. A.) 86: 8242-8246 Abstract: Notes:

	Vellarkad N Viswanadhan, Arup K Ghose, Ganapathi R Revankar, Roland K Robins (1989) Atomic Physicochemical Parameters for Structure Directed Three Dimensional Structure-Activity Relationships: IV Additional Parameters for Hydrophobic and Dispersive Interactions and Their Uses in Molecular Superpositions J. Chem. Info. and Comput. Sci. 29: 163-172 Abstract: Notes:
1988	Francisco Mendecuti, Vellarkad N Viswanadhan, Wayne L Mattice (1988) Dependence Of The Occupancy of Excimer-Forming Conformations On The Size of The Flexible Spacer in Polyesters From Terephthalic Acid And Mono, Di, Or Tri-Ethylene Glycol Polymer 29: 875-879 Abstract: Notes:
	Wolfgang R Bergmann, Vellarkad N Viswanadhan, Wayne L Mattice (1988) Conformations of Polymeric Proanthocyanidins Composed of (+)-catechin or (-)-epicatechin Joined by 4 -> 6 Inter-flavan bonds J. Chem. Soc. Perkin Tran. II 45-47 Abstract: Notes:
	Francisco Mendecuti, Bharat Patel, Vellarkad N Viswanadhan, Wayne L Mattice (1988) Identification of Conformations Conducive to Intramolecular Excimer Formation in Polyesters with Different Numbers of Methylene Units between Aromatic Rings Polymer 29: 1669-1674 Abstract: Notes:
	Vellarkad N Viswanadhan, Wayne L Mattice (1988) Conformations of Monomers and Dimers of 2,3-trans and 2,3-cis Flavan-3-0ls With Differing Hydroxylation Patterns In The B-ring Int. J. Biol. Macromolecules 10: 209-212 Abstract: Notes:
	Vellarkad N Viswanadhan, Wayne L Mattice (1988) Configurational Statistics of C(4)-C(8) linked Polymers of (+)-catechin or (-)-epicatechin with Mixed Axial/Equatorial Substituents at C(2) Int. J. Biol. Macromolecules 10: 9-14 Abstract: Notes:
1987	Vellarkad N Viswanadhan (1987) Hydrophobicity and Residue-residue Contacts in Globular Proteins Int. J. Biol. Macromolecules 9: 39-48 Abstract: Notes:
	Vellarkad N Viswanadhan (1987) On the Prediction of Functionally Equivalent Residues at Given Sites in Proteins J. Theor. Biol. 124: 123-125 Abstract: Notes:
	Vellarkad N Viswanadhan, Wayne L Mattice (1987) Assessment of Bond Rotational Interdependence in Polymer Chains: An Information Theory Approach Macromolecules 20: 685-688 Abstract: Notes:
	Vellarkad N Viswanadhan, Wolfgang R Bergmann, Wayne L Mattice (1987) Configurational Statistics of C(4)-C(8) linked homopolymers of (+)-catechin and (-)-epicatechin Macromolecules 20: 1539-1544 Abstract: Notes:

	Vellarkad N Viswanadhan, Wayne L Mattice (1987) Assessment by Molecular Mechanics of the Preferrerd Conformations of the Sixteen C(4)-C(6) and C(4)-C(8) linked dimers of (+)-catechin and/or (-)-epicatechin with axial or equatorial substituents at C(2) J. Chem. Soc. Perkin Trans. II 739-744 Abstract: Notes:
1986	Wayne L Mattice, V N Viswanadhan (1986) Stereochemical Selectivity in the Formation of CH2RCHRCH2CHRCH2- Branches in the Free Radical initiated Polymerizatlon of Vinyl Monomers Macromolecules 19: 568-571 Abstract: Notes:
	V N Viswanadhan, Wayne L Mattice (1986) Conformational Analysis of the Sixteen C(4)-C(6) and C(4)-C(8) linked dimers of (+)-catechin and (-)-epicatechin J. Comput. Chem. 7: 711-717 Abstract: Notes:
	Lawrence J Porter, Rosalind Y Wong, Mary Benson, Bock G Chan, V N Viswanadhan, Richard D Gandour, Wayne L Mattice (1986) Conformational Analysis Flavans: H1-N.m.r. and Molecular Mechanical (MM2) studies of the Benzpyran Ring of 3',4',5,7-Tetrahydroxyflavan-3-ol's: the Crystal and Molecular Stucture of the Procyanidin (2R,3S,4R)-3'4,5,7-Tetramethoxy-4-(2,4,6-trimethoxyphenyl) flavan-3-ol J. Chem. Res. (S), J. Chem. Res. (M) 86-87; 0830-0880 Abstract: Notes:
1985	V N Viswanadhan, Wayne L Mattice (1985) Poly(vinyl acetate) as a Test of Roedel Mechanism for Short Branch Formation Makromol. Chem. 186: 633-640 Abstract: Notes:
	G M Crippen, V N Viswanadhan (1985) Side chain and Backbone Potential Function for the Conformational Analysis of Proteins Int. J. Peptide and Protein Res. 25: 487-509 Abstract: Notes:
	V N Viswanadhan, Wayne L Mattice (1985) Short Branch Formation via Roedel Mechanism in Copolymers of Ethylene and Vinyl Acetate J. of Polymer Science: Polymer Physics Edition 23: 1957-1965 Abstract: Notes:
1984	G M Crippen, V N Viswanadhan (1984) A Potential Function for the Conformational Analysis of Proteins Int. J. Peptide and Protein Res 24: 279-296 Abstract: Notes:
1983	V N Viswanadhan, K Sundaram (1983) Structural Conservation in Globular Proteins Int . J. Peptide and Protein Res. 21: 190-195 Abstract: Notes:
	K Sundaram, V N Viswanadhan, R D MacElroy (1983) Information Contained in Protein Shapes Int . J. Peptide and Protein Res. 21: 107-117 Abstract: Notes:
	V N Viswanadhan, K Sundaram (1983) Specificity of Spatial Association of Amino Acid Residues as an Evolutionary Trend in Proteins Int . J. Peptide and Protein Res. 22: 73-77 Abstract: Notes:
1982	V N Viswanadhan, K Sundaram (1982) Chain Phase Trajectory of a Protein Molecule Int . J. Peptide and Protein Res. 20: 371-379 Abstract: Notes:
	V N Viswanadhan, K Sundaram (1982) Amino Acid Residues at Conserved Sites in Proteins Physiol. Chem. & Phys. 14: 179-181 Abstract: Notes:
1980	K Sundaram, V N Viswanadhan (1980) Moment of Inertia Ellipsoids of Proteins of Known Structure Physiol. Chem. and Phys. 12: 187-191 Abstract: Notes:
Book chapters

2001	Arup K Ghose, Vellarkad N Viswanadhan, John J Wendoloski (2001) Fundamentals of Pharmacophore Modeling for Combinatorial Chemistry" in Combinatorial Library Design and Evaluation for Drug Discovery In: Combinatorial Library Design and Evaluation for Drug Discovery: Principles, Software Tools and Applications in Drug Discovery Edited by:Arup K. Ghose and Vellarkad N. Viswanadhan. 51-72 New York: Marcel-Dekker Abstract: Notes:
	Vellarkad N Viswanadhan, Arup K Ghose, Alex Kiselyov, John N Weinstein, John J Wendoloski (2001) Knowledge-based Approaches for the Design of Small Molecule Libraries for Drug Discovery In: Combinatorial Library Design and Evaluation for Drug Discovery: Principles, Software Tools and Applications in Drug Discovery Edited by:Arup K. Ghose and Vellarkad N. Viswanadhan. 267-289 New York: Marcel-Dekker Abstract: Notes:
1999	M Rami Reddy, Vellarkad N Viswanadhan, Mark D Erion (1999) Rapid Estimation of Relative Binding Affinities of Enzyme Inhibitors In: 3D-QSAR in Drug Design: Ligand Protein Interactions and Molecular Similarity Edited by:Kubinyi, H., Folkers, G., Martin, Y. C.. 85-98 The Netherlands: Kluwer Abstract: Notes:
	Arup K Ghose, Vellarkad N Viswanadhan, John J Wendoloski (1999) Adapting Structure-based Drug Design in the paradigm of Combinatirial Chemistry and High Throughput Screening: An Overview and New Examples with Important Caveats for Newcomers to Combinatorial Library Design using Pharmacophore Models or Multiple Copy Simultaneous Search Fragments In: Rational Drug Design Edited by:Parrill, A. and Reddy, M. R.. 226-238 Washington, D. C.: American Chemical Society Abstract: Notes:
1985	V N Viswanadhan (1985) Cooperative Interactions in Globular Proteins: Analysis of Protein Crystal Structures In: Molecular Basis of Cancer Edited by:R. Rein. 125-132 Abstract: Notes:
1984	K Sundaram, V N Viswanadhan (1984) Protein Information and the Living State In: The Living State Edited by:R. K. Mishra. 262-277 Abstract: Notes:
1982	K Sundaram, V N Viswanadhan (1982) Towards Measuring Information Contained in the Shapes of Proteins In: Biochemical and Biophysical Information Transfer in Recognition Edited by:J. G. Vassileva-Popova and E.V. Jensen. 434-437 New York and London: Plenum Press Abstract: Notes:
PhD theses

1982	V N Viswanadhan (1982) Theoretical Studies on Proteins Through Quantitative Attributes of Their 3D-Structures University of Madras, Department of Crystallography and Biophysics Guindy Campus, Chennai, India: Abstract: Notes:
Masters theses

1977	V N Viswanadhan (1977) Indexing X-ray Powder Diffraction Pattern on the Digital Computer University of Hyderabad Abstract: Notes:

Books

Journal articles

Book chapters

PhD theses

Masters theses