Abstract: Stroke is the third common cause of mortality and the most common cause of morbidity in adults. MLC601 (NeuroAiDâ„¢) is a treatment indicated for post stroke recovery. An increase of impaired cerebral blood flow may be an important parameter for recovery processes. The aim of this study was to investigate the effect of MLC601 on cerebral blood flow velocity as an indirect evidence of cerebral blood flow increase in post stroke subjects.
Abstract: Background and Objective: Diabetes mellitus is one of the most common diseases in general population. Its prevalence is 5-8 percent in Iran. The disease has symptoms such as neuropathy. The prevalence of neuropathy is equivalent to 7 percent at onset of the disease, but as the underlying disease advances the prevalence of neuropathy can reach to as much as 50 percent. In some patients with neuropathy, the neuropathic pain can affect their daily functioning and quality of life.Subjects and Methods: The subjects of this clinical trial were 60 patients with type 2 diabetes mellitus who referred to diabetes clinic of Ahvaz Golestan hospital. After proving painful neuropathy, and according to their history, physical examination and EMG-NCV, and considering their inclusion and exclusion criteria for the study, they were randomly divided into two equal groups. The study was accomplished in a double blind method. One group was treated with amitriptyline (50 mg / d) and the other group was treated with carbamazepine (200mg TID). Based on brief pain inventory quantitative scale amount of pain was scored before and six weeks after the beginning of study. Results: Both drugs were found effective, but no significant difference in pain relief was noted. Hb A1C in patients who received carbamazepine was found lower in comparison with other group. Conclusion: If the glucose declining effect of carbamazepine would be proved in the future, it can be administered as an adjunct therapy. Sci Med J 2011;10(5):515-25
Abstract: Topiramate is an antiepileptic drug that has been approved for migraine prophylaxis. Despite appropriate efficacy for migraine prophylaxis, some patients cannot tolerate its adverse effects. The aim of this study was to compare the efficacy of zonisamide, another antiepileptic drug, with topiramate in decreasing the frequency and severity of migraine attacks to determine whether it could be used as an alternative for noncompliant patients to topiramate.
Abstract: This randomized-double-blind aimed to show the effect of middle dose of topiramate and monitor the sodium valproate as a treatment quite acceptable in migraine prophylaxis as well as compare health and treatment effects in reducing both frequency and the severity of headache. Seventy-three females patients filled questionnaire based on the migraine disability assessment score (MIDAS) in the beginning and end of the study. Frequency, severity, duration of headache attacks and symptoms of drug in each of the patients are listed in his file. The effects of middle dose of topiramate (50-75 mg) and sodium valproate (400-600 mg) in the prevention of migraine headache was compared. Out of the 73 patients three cases were excluded due to unwanted and adverse events. Although, both drugs have been successful in reducing headache frequency more than 50% within the study, but there was no significant difference. The MIDAS score in topiramate group reduced more than the group receiving valproate sodium, which indicates changes, was statistically significant in both groups before treatment. The most common complications recorded in the group receiving topiramate were, paresthesia followed by weight loss, drowsiness and dizziness in topiramate group. While, the most common complications recorded in the group receiving sodium valproate were, drowsiness, weight gain, hair loss, nausea and Tremor. This trial demonstrates that topiramate significantly reduced mean monthly migraine and was a safe and well-tolerated preventive therapy in this group of subjects with migraine, a therapeutic area in which profound clinical needs exist.
Abstract: Childhood hypertension has been extensively focused on in the past decades because of its increasing incidence, which is related to physicians' awareness and the increasing number of obese children. Age, gender, and body size are the main determinants of blood pressure in children. The revised childhood blood pressure tables of the National High Blood Pressure Education Program are a prerequisite for classification of childhood hypertension. Although these tables provide a reasonable basis, they are intricate and height percentile is needed for final diagnosis. Many attempts have been done to decrease such complexity. We present new formulas that are concise and memorable, and will help physicians to screen prehypertensive and hypertensive pediatric patients.
Abstract: Multicystic dysplastic kidney is a noninherited congenital disease. Association of this disease with abnormalities of various organs is common. We, however, report a rare case of multicystic dysplastic kidney associated with congenital ichthyosiform erythroderma in an infant. Different developmental origins of the skin and the kidney can explain the scarcity of concurrent congenital skin and kidney abnormalities. Nonetheless, the development of both organs depends on mesenchyme-epithelial interactions for inductive signaling. It seems defects in the production of signaling molecules can explain such an association.
Abstract: Introduction: G6PD Deficiency is the most common enzyme deficiency in all over the world. The prevalence of this defect differs in the different parts of the world (from 0.1 to 50 percent). Clinical complications such as Acute Hemolytic Anemia and Neonatal Jaundice are common in areas that materials which have oxidant factor such as Fava bean is used excessively.
Objective: Study of the prevalence of this defect in Rasht.
Materials and Methods: In this cross-sectional study, 605 male and 585 female neonates were examined by FST (Fluorescent Spot Test) in 17 Shahrivar Hospital.
Results: 59 males (9.8%, CI 95%=7.5-12.5%) and 18 females (3.1%, CI 95%= 1.9-4.9%) were detected as G6PD Deficient. Total prevalence was 6.4 percent (CI 95%: 5-8 percent). It is obvious that G6PD Deficiency in males was more than females (p<0.001, RR=3.3). There was no significant relation between G6PD Deficiency and being term or preterm (p>0.1).
Conclusion: Because G6PD is sex related, its three times more prevalence in male compared with female in expected. This deficiency is more common in south compared with north of Iran (probably because of malaria) but the excessive use of Fava bean is the main reason for incidence of its complications in this area, then, the wise policy would be screening neonates and instruction parents.
Abstract: Background&Purpose: Although sickle cell disease (SCD) is strongly linked to stroke across all haplotypes in the pediatric population, Iranian children with Saudi-Asian haplotype are less affected by this complication. TCD is known to identify the highest risk group in African-Americans who need to receive and stay on blood transfusions, but it is unclear if the same flow velocity cut-offs can be applied to the Iranian population. We therefore aimed first to evaluate baseline TCD findings in Iranian children with SCD and no prior strokes.
Subjects&Methods: Children with genetically confirmed SCD (Arabian haplotype, homozygote) and without SCD (controls) aged 3 to 16 years were prospectively recruited from pediatric outpatient clinic over a period of 9 months. All children had no previous stroke or any neurologic deficit. No transfusion was given within one month prior to TCD examination and patients were not on any medication that may affect cerebral hemodynamics. We performed TCD examinations in both groups to determine flow velocities in the middle cerebral (MCA) and terminal internal carotid arteries (TICA). Mann-Whitney U test was used to compare TCD variables between the two groups.
Results: Of 74 screened children, 60 met the inclusion/exclusion criteria (62% female; mean age 10±4 years). Baseline characteristics did not differ between the cases and controls, except hemoglobin (Hb) which was significantly lower in the SCD group (mean 8.83±1.43 g/dL vs. 10.3±1.03 g/dL, p<0.001). In children with SCD, the highest MCA MFV (92 cm/s vs. 67 cm/s, p<0.001) and the highest TICA MFV (62 cm/s vs. 45 cm/s, p<0.001) were significantly higher than in controls. Among asymptomatic Iranian children with SCD only 1/30 (3%) had conditional >170 cm/s MFV.
Conclusions: Among Iranian children with asymptomatic SCD and without receiving recent transfusion TCD velocities could be much lower than those observed in STOP studies, and some of the high risk group may be identified with velocities lower than 170 cm/s. A prospective validation of ethnicity-specific diagnostic criteria is warranted.
