Abstract: To assess whether age-related differences in suppressing nontarget material impact subsequent performance, the authors initially asked younger and older adults to perform a go/nogo task with colored letters used as conflicting go/nogo stimuli and 2 colored numbers as low-conflict nogo stimuli. Next, participants performed another go/nogo task. A previous number was reused as a nogo stimulus and the other as a go stimulus, with new numbers serving as a baseline. In a 1st block of trials, younger adults showed slower responses to previous nogo/now-go numbers than to new go numbers, an effect not shown by older adults. Alternative accounts of these differential transfer costs are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved).
Abstract: Abstract The ability to step outside a routine-to select a new response over a habitual one-is a cardinal function of the frontal lobes. A large body of neuroimaging work now exists pointing to increased activation within the anterior cingulate when stimuli evoke competing responses (incongruent trials) relative to when responses converge (congruent trials). However, lesion evidence that the ACC is necessary in this situation is inconsistent. We hypothesized that this may be a consequence of different task procedures (context) used in lesion and neuroimaging studies. The present study attempted to reconcile the lesion and the fMRI findings by having subjects perform clinical and experimental versions of the Stroop task during BOLD fMRI acquisition. We examined the relationship of brain activation patterns, specifically within the anterior cingulate and left dorsolateral frontal regions, to congruent and incongruent trial types in different task presentations or contexts. The results confirmed our hypothesis that ACC activity is relatively specific to unblocked-uncued incongruent Stroop conditions that have not been used in large neuropsychological studies. Moreover, the size of the behavioral Stroop interference effect was significantly correlated with activity in ACC and left dorsolateral regions, although in different directions. The current results are discussed in terms of previous proposals for the functional roles of these regions in activating, monitoring, and task setting, and the relation of these findings to the disparate reports in recent case series is considered.
Abstract: Problems in suppressing neural activity related to distracting information increase with age. We investigated whether age-related changes in processing non-target material are present even when behavioral performance is matched between age groups. Younger (19-36 years) and older (61-80 years) participants performed a go/nogo task with different degrees of cognitive interference for two types of nogo stimuli. On each block, either the left or the right hand was used for the go responses. EEG was recorded to compute the Lateralized Readiness Potential (LRP), a measure of unilateral motor response preparation. Although performance was similar in the two groups, older adults showed a pronounced LRP partial response preparation not only for high-conflict nogo stimuli, but even for low-conflict ones, when both age groups performed at ceiling. These results indicate that, even without age-related performance differences, older individuals show enhanced response preparation to non-target stimuli that can be detected with more sensitive measures such as the LRP. Negative correlations between nogo-LRPs and go-RTs in the older group only suggest the possibility that partial response preparation for nogo stimuli is the cost to pay to maintain optimal speed to go stimuli in normal aging.
Abstract: Abstract This study used functional magnetic resonance imaging (fMRI) to investigate the neural effects of increasing cognitive demands in normal aging and their role for performance. Simple and complex go/no-go tasks were used with two versus eight colored letters as go stimuli, respectively. In both tasks, no-go stimuli could produce high conflict (same letter, different color) or low conflict (colored numbers) with go stimuli. Multivariate partial least square analysis of fMRI data showed that older adults overengaged a cohesive pattern of fronto-parietal regions with no-go stimuli under the specific combination of factors which progressively amplified task demands: high conflict no-go trials in the first phase of the complex task. This early neural overrecruitment was positively correlated with a lower error rate in the older group. Thus, the present data suggest that age-related extra-recruitment of neural resources can be beneficial for performance under taxing task conditions, such as when novel, weak, and complex rules have to be acquired.
Abstract: Functional hemispheric asymmetry can be lost with aging. In this electroencephalographic study, we assessed hemispheric asymmetries in regulating motor responses by analyzing oscillatory brain activity during a go/nogo task in younger and older right-handed participants. Three conditions were embedded in the task: go, high-conflict and low-conflict nogo. The hand used to respond to go stimuli was varied block-wise. Independently of the go/nogo conditions and responding hand, young participants showed asymmetric desynchronizations in the mu (10 Hz) and beta (18-22 Hz) frequency bands that was stronger in the scalp sensorimotor region contralateral to the hand used for the go responses, while older adults showed a more symmetric pattern of desynchronization. These findings indicate that a loss of hemispheric asymmetry is a hallmark of the aging motor system, consistent with a decline of inter-hemispheric motor inhibition in normal aging.
Abstract: That the left prefrontal cortex has a critical role setting response criteria for numerous tasks has been well established, but gaps remain in our understanding of the brain mechanisms of task-setting. We aimed at (i) testing the involvement of this region in setting the criteria for a non-response and (ii) assessing functional connectivity between this and other brain regions involved in task-setting. Fourteen young participants performed a go/nogo task during functional magnetic resonance imaging. The task included two nogo visual stimuli which elicit a high (distractor) or a low (other) tendency to respond, respectively. Two task blocks were examined to assess learning the criteria. First, a multivariate Partial Least Squares (PLS) analysis identified brain regions that co-varied with task conditions, as expressed by two significant Latent Variables (LVs). One LV distinguished go and nogo stimuli. The other LV identified regions involved in the first block when the criteria not to respond to distractors were established. The left prefrontal region was prominently involved. Second, a left ventrolateral prefrontal area was selected from this LV as a seed region to perform functional connectivity using a multi-block PLS analysis. Results showed a distributed network functionally connected with the seed, including superior medial prefrontal and left superior parietal regions. These findings extend our understanding of task-setting along the following dimensions: 1) even when a task requires withholding a response, the left prefrontal cortex has a critical role in setting criteria, and 2) this region responds to the task demands within a distinctive functional network.
Abstract: Time processing may shape behavior in several ways, although the underlying neural correlates are still poorly understood. When preparatory intervals between stimuli vary randomly in a block, for instance, responses are faster as the interval gets longer. This effect, known as variable foreperiod (FP) effect, has been attributed to a process monitoring the conditional probability of stimulus occurrence as the interval increases. Previous evidence points to the right dorsolateral prefrontal cortex (DLPFC) as a possible node for this time-monitoring process. The present study addresses this hypothesis with functional magnetic resonance imaging (fMRI). Block-design fMRI was used on 14 young participants while they performed a visual discrimination task with fixed and variable preparatory intervals (FPs) of 1 and 3 sec. In the variable versus fixed FP contrast, the right DLPFC and a visual area were more activated in the subgroup of participants who showed a reliable variable FP effect than in another subgroup who did not show that effect. Only the activation in the right DLPFC was supported by a significant interaction between FP condition (variable vs. fixed) and group. This finding may reflect possible differences in the strategy adopted by the two subgroups of participants while performing the task. Although results suggest that many brain areas may be involved in preparation over time, the role of the right DLPFC is critical to observe the strategically mediated behavioral effects in the variable FP paradigm.
Abstract: The embodied cognition hypothesis suggests that motor and premotor areas are automatically and necessarily involved in understanding action language, as word conceptual representations are embodied. This transcranial magnetic stimulation (TMS) study explores the role of the left primary motor cortex in action-verb processing. TMS-induced motor-evoked potentials from right-hand muscles were recorded as a measure of M1 activity, while participants were asked either to judge explicitly whether a verb was action-related (semantic task) or to decide on the number of syllables in a verb (syllabic task). TMS was applied in three different experiments at 170, 350 and 500 ms post-stimulus during both tasks to identify when the enhancement of M1 activity occurred during word processing. The delays between stimulus onset and magnetic stimulation were consistent with electrophysiological studies, suggesting that word recognition can be differentiated into early (within 200 ms) and late (within 400 ms) lexical-semantic stages, and post-conceptual stages. Reaction times and accuracy were recorded to measure the extent to which the participants' linguistic performance was affected by the interference of TMS with M1 activity. No enhancement of M1 activity specific for action verbs was found at 170 and 350 ms post-stimulus, when lexical-semantic processes are presumed to occur (Experiments 1-2). When TMS was applied at 500 ms post-stimulus (Experiment 3), processing action verbs, compared with non-action verbs, increased the M1-activity in the semantic task and decreased it in the syllabic task. This effect was specific for hand-action verbs and was not observed for action-verbs related to other body parts. Neither accuracy nor RTs were affected by TMS. These findings suggest that the lexical-semantic processing of action verbs does not automatically activate the M1. This area seems to be rather involved in post-conceptual processing that follows the retrieval of motor representations, its activity being modulated (facilitated or inhibited), in a top-down manner, by the specific demand of the task.
Abstract: Ignoring irrelevant information becomes more difficult with increasing age. The present cross-sectional study addressed this issue by investigating age-related differences in the ability to withhold a response to non-target stimuli. Fourteen young (20-34 years) and 14 elderly (60-80 years) participants performed two go/nogo tasks (simple vs. complex). In the simple task the subjects responded to red O and blue X (target go stimuli) while withholding responses to the blue O and red X (conflict nogo stimuli) and to numbers of either color (irrelevant nogo stimuli). In the complex version, 4 vowels and 4 consonants were used instead of O and X. Accuracy, response times (RTs) and event-related potentials (ERPs) were recorded. Both young and elderly groups made more commission errors to conflict nogo stimuli (mean 5% and 8% in the simple and complex tasks, respectively, age differences not significant) than to irrelevant nogo stimuli (mean<1%), indicating difficulty in withholding a response when a pertinent stimulus feature (letter identity) was shared with the go stimuli. In addition to later RTs to go stimuli and later P3 waves for the conflicting stimuli than the young group, elderly participants showed a very prominent left posterior P2 and a large pre-central P3 to the irrelevant nogo stimuli. These findings suggest that elderly have difficulty in ignoring irrelevant nogo stimuli even when they are easily distinguishable from the go stimuli.
Abstract: The inferential system anticipates the external environment by building up internal representations of its regularities. To that purpose, two sources of information are especially important and attract attentional resources: expected and unexpected events, which are useful for checking the accuracy of internal representations. In the present study, we investigated the behavioural properties and the neural mechanisms underlying the strategic allocation of attention triggered by those events. To that end, event-related potentials (ERPs) were recorded during the performance of two tasks requiring detection of predictable and unpredictable response events embedded in a visuospatial or numeric sequence. The behavioural results in the two tasks mirror each other, suggesting the recruitment of similar attentional allocation processes between the two domains. The ERPs showed partially similar effects. In both tasks, a P3a-like component signalled the capture of attention by events clashing with previous expectations, whilst a P3b-like component marked the focusing of attention on predicted events and its redistribution among all possible response events occurring after the detection of an unexpected event.
Abstract: Evidence on the processes underlying the horizontal and vertical Simon effect is still controversial. The present study uses experimental manipulations to selectively delay the stages of response execution, response selection, and stimulus identification in three experiments. A reduction is observed for both horizontal and vertical Simon effects when response execution is delayed by a go-signal presented 400-600 ms post-stimulus onset or when a spatial precue is presented 200-400 ms before the stimulus. When the overlap between stimulus spatial code formation and response selection is prevented by decreasing stimulus discriminability, the horizontal Simon effect decays, but the vertical Simon effect does not change. Activation theories, which propose a decay of the automatically activated response ipsilateral to the stimulus, mainly apply to the horizontal Simon effect. In contrast, translation theories, which propose that the effect occurs when stimulus features are translated into a response code, are more suitable to account for the vertical Simon effect.
Abstract: Behavioural evidence suggests a left-to-right directionality in the representation of elapsing time. We tested whether this representation produces a spatial attentional shift that activates a corresponding left-to-right spatial response code. Fourteen participants judged whether a cross lasted for a short (1sec) or a long (2sec) duration with left and right responses, respectively, or vice versa, while event-related potentials (ERPs) were measured. Responses were faster when participants judged short and long durations with their left and right hand, respectively, than vice versa. In these compatible conditions only (short-left; long-right), ERP negativity developed over the right motor scalp region around the short duration, a finding that is compatible with an early pre-activation of left-hand responses, and over the left motor region around the long duration, suggesting a later pre-activation of right hand responses. These findings confirm that in this task elapsing time is represented from left to right, and that this representation generates corresponding response codes that influence performance.
Abstract: The present study focused on the processes underlying cognitive association formation by investigating subsequent memory effects. Event-related potentials were recorded as participants studied pairs of words, presented one word at a time, for later recall. The findings showed that a frontal-positive late wave (LW), which occurred 1-1.6s after the presentation of the second word of a pair during study, was associated with later paired associate recall. The observed LW likely reflected cognitive association formation processing. Paired associate recall was also associated with a larger P555 to each word of a pair, likely reflecting the encoding of each individual word of a pair, which necessarily precedes association formation between the two words. Moreover a larger N425 was elicited by pairs that were encoded in a low context-similarity condition compared to that of a high context-similarity condition, likely reflecting semantic integration. Minimum norm source analyses showed that the likely sources of these ERP effects changed dynamically in time: a widespread fronto-temporo-parietal activation during the N425 was followed by a fronto-temporal activation during the P555, and finally by a left prefrontal activation during the LW.
Abstract: Young and elderly adults performed a choice-RT task while scanned with functional magnetic resonance imaging. A foreperiod separated a warning and a response signal. In the variable condition, the foreperiod varied randomly between 1 and 3s. In the fixed conditions, it was kept constant at either 1 or 3s. Elderly subjects responded slower than controls in both task conditions. An interaction was observed between age and foreperiod in the variable condition only: in the young group, RT decreased with longer foreperiods, whereas the elderly participants showed the opposite tendency. This was accompanied by difference in brain activation. Right lateral prefrontal regions were more activated in the young than in the elderly group in the variable vs. fixed foreperiod contrast. These findings unveil the neural substrate of age-related preparation deficits, and confirm that the involvement of right lateral prefrontal cortex is essential for strategic preparation under uncertain timing conditions.
Abstract: The present study addresses the question of how such an abstract concept as time is represented by our cognitive system. Specifically, the aim was to assess whether temporal information is cognitively represented through left-to-right spatial coordinates, as already shown for other ordered sequences (e.g., numbers). In Experiment 1, the task-relevant information was the temporal duration of a cross. RTs were shorter when short and long durations had to be responded to with left and right hands, respectively, than with the opposite stimulus-response mapping. The possible explanation that the foreperiod effect (i.e., shorter RTs for longer durations) is greater with right than with left hand responses is discarded by results of Experiment 2, in which right and left hand responses alternated block-wise in a variable foreperiod paradigm. Other explanations concerning manual or hemispheric asymmetries may be excluded based on the results of control experiments, which show that the compatibility effect between response side and cross duration occurs for accuracy when responses are given with crossed hands (Experiment 3), and for RTs when responses are given within one hand (Experiment 4). This pattern suggests that elapsing time, similarly to other ordered information, is represented in some circumstances through an internal spatial reference frame, in a way that may influence motor performance. Finally, in Experiment 5, the temporal duration was parametrically varied using different values for each response category (i.e., 3 short and 3 long durations). The compatibility effect between hand and duration was replicated, but followed a rectangular function of the duration. The shape of this function is discussed in relation to the specific task demands.
Abstract: The involvement of right dorsolateral prefrontal cortex (rDLPFC) in explicit temporal processing is well documented. Conversely, the role of this area in implicit temporal processing (e.g., foreperiod [FP] effect) is still poorly understood. The FP effect, usually observed when a range of variable FPs occur randomly and equiprobably, consists of reaction times (RTs) decreasing as the FP increases. Moreover, in such paradigms, RTs increase as a function of the preceding FP (i.e., sequential effects). Patients with lesions of the rDLPFC do not show the typical FP effect. The present study aimed to replicate these results in healthy adults using transcranial magnetic stimulation (TMS) and to further investigate whether any change of sequential effects follows a reduction of the FP effect. The results of 2 experiments (with simple and choice RT tasks, respectively) indicate that the FP effect was significantly reduced after TMS over the rDLPFC, whereas no effect was observed after stimulation of a left contralateral site and the right angular gyrus. Conversely, sequential effects were not influenced by TMS. A dual-process model of the FP phenomena is proposed to interpret the dissociation found between the 2 effects.
Abstract: When foreperiods (FPs) of different duration vary on a trial-by-trial basis equiprobably but randomly, the RT is faster as the FP increases (variable FP effect), and becomes slower as the FP on the preceding trial gets longer (sequential effects). It is unclear whether the two effects are due to a common mechanism or to two different ones. Patients with lesions on the right lateral prefrontal cortex do not show the typical FP effect, suggesting a deficit in monitoring the FP adequately [Stuss, D. T., Alexander, M. P., Shallice, T., Picton, T. W., Binns, M. A., Macdonald, R., et al. (2005). Multiple frontal systems controlling response speed. Neuropsychologia, 43, 396-417]. The aim of this study was two-fold: (1) to replicate this neuropsychological result testing cerebral tumor patients before and after surgical removal of the tumor located unilaterally in the prefrontal, premotor or parietal cortex, respectively and (2) to investigate whether the sequential effects would change together with the FP effect (supporting single-process accounts) or the two effects can be dissociated across tumor locations (suggesting dual-process views). The results of an experiment with a variable FP paradigm show a significant reduction of the FP effect selectively after excision of tumors on right prefrontal cortex. On the other hand, the sequential effects were reliably reduced especially after surgical removal of tumors located in the left premotor region, despite a normal FP effect. The latter dissociation between the two effects supports a dual-process account of the variable FP phenomena. This study demonstrates that testing acute cerebral tumor patients represents a viable neuropsychological approach for the fractionation and localisation of cognitive processes.
Abstract: In a variable foreperiod (FP) paradigm, reaction times (RTs) decrease as a function of FP on trial n (FP effect) but increase with FP on trial n - 1 (sequential effects). These phenomena have traditionally been ascribed to different strategic preparation processes. According to an alternative explanation, common conditioning laws underlie both effects. The present study aims to disentangle these opposite views using a developmental perspective. In Experiment 1A, 4- to 11-year-old children and a control group of adults performed a simple RT task with variable FPs (1, 3, and 5 s). Furthermore, 12 4- to 5-year-old children were retested after 14 months (Experiment 1B). In Experiment 2, a narrower pool of participants (4, 5, and 6 years old) performed a variable FP paradigm with different FPs (1, 2, and 3 s). The results consistently suggest different ontogenetic time courses for the two effects: The sequential effects are already present in the youngest group (4-5 years old), whereas the FP effect appears gradually some years later. These findings are not fully compatible with previous views. A dual-process account is proposed to explain the data.
Abstract: OBJECTIVE: This study aims to evaluate the efficiency of top-down and bottom-up processes in the extrastriate cortex of cirrhotic patients without overt hepatic encephalopathy (HE). METHODS: Reaction times (RTs), accuracy and event-related potentials (ERPs) were recorded during the execution of a visual Simon task in 17 cirrhotic patients and 10 healthy controls. Amplitude and latency of the P1 and N1 (indexes of bottom-up processes) and of the N2pc (index of top-down processes) were measured. RESULTS: Patients were slower than controls, and patients with minimal HE (MHE) were slower than patients without MHE. The distribution analysis of RTs showed that the Simon effect decays with slower RTs in all the groups and that the shape of the distribution was different in MHE patients. No differences were found between cirrhotic patients and controls for P1 and N1 amplitude and latency. In contrast, N2pc latency was delayed in cirrhotic patients compared to controls independently of MHE. CONCLUSIONS: In the extrastriate cortex of cirrhotic patients without HE, top-down processes are altered whereas bottom-up processes are preserved. SIGNIFICANCE: The analysis of exogenous and endogenous visual components of ERPs provides a model to study the functional dissociation between top-down and bottom-up processes inside the extrastriate cortex.
Abstract: Although a prefrontal involvement in the memory domain is well-documented, the specific functions the frontal lobes have in episodic memory are still unclear. This study aimed to disentangle theoretical accounts of prefrontal involvement concerning objective characteristics of the retrieval (i.e., accuracy) and accounts based on subjective features (i.e., confidence). Event-related potentials (ERPs) were recorded during the test phase of a source memory task in two experiments. The task was to retrieve the word and the voice of the speaker at study (experiment 1) or the voice of the speaker together with confidence ratings about the source judgment (experiment 2). ERPs in both experiments were not modulated by the success of the voice retrieval, discarding accounts linked to the retrieval success. A right-more-than-left late prefrontal positivity was found in both experiments. Moreover, in experiment 2, waves were more positive for low- than for high-confidence responses. This pattern was observed earlier over lateral parietal scalp regions and later, and more sustained in time, over anterior prefrontal regions. The dissociable effects found within the prefrontal scalp regions, specifically along the anterior-posterior and right-left dimensions, are interpreted as markers of qualitatively different monitoring processes.
Abstract: Reaction times are usually faster when stimulus and response occur at the same location than when they do not, even if stimulus location is irrelevant to the task (Simon effect). This effect was found with both horizontal and vertical stimulus-response arrangements. The same mechanisms have been proposed to be involved in either case. Here, we compared a horizontal and a vertical Simon task by means of a RT time-course analysis of the Simon effect. Also, we analysed the lateralised readiness potential (LRP), an index of covert response-preparation processes. In the horizontal task, the Simon effect decays over time and pre-activation occurs above the motor cortex ipsilateral to the stimulus. In contrast, the Simon effect does not decay over time and no early incorrect LRP deflection is observed in the vertical task. These findings suggest that typical activation accounts can fit only the horizontal Simon effect, while a translation explanation is more suitable for the vertical Simon effect.
Abstract: Abnormality in movement initiation may partially explain psychomotor delay of cirrhotic patients, even in the absence of overt hepatic encephalopathy (HE). Therefore, the aim of this study was to determine the mechanisms of psychomotor delay observed in patients with cirrhosis in the absence of overt HE. Fourteen patients with nonalcoholic cirrhosis and 12 healthy matched control subjects underwent the lateralized readiness potential (LRP) measurement elicited by a visuospatial compatibility task (Simon task). Stimulus-triggered LRPonset reflects the time in which response is selected, while response-triggered LRP onset reflects motor execution. Cirrhotic patients showed delayed reaction times (RTs) compared to controls, particularly those with trial-making test A (TMT-A) or electroencephalogram (EEG) alterations. Stimulus-triggered LRP onset was found to be delayed in cirrhotic patients compared to controls, with a significant Group-versus-Condition interaction, showing a reduced cognitive ability to cope with interfering codes, even in patients without minimal HE (MHE). Response-triggered LRP was found to be delayed only in the patients with TMT-A or EEG alterations. In conclusion, cirrhotic patients without overt HE display a psychomotor slowing, depending first lyon response inhibition and only later accompanied by impaired motor execution.
