Department of Chemistry, College of Science and Arts, Ulla , Tahiba University, El- Madinah, Saudi Arabia.
E-Mail: youserysherif1965@yahoo.com or youserysherif@gamil.com
Phone: +966-0594369403 (mobile).
Egypt : 0020507929005
Permenent Address
Department of Pharmacology, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt.
youserysherif@gmail.com
B.Sc. (Distinction) Major Chemistry 1989 Department of Chemistry, Faculty of Science, Mansoura University. M.Sc. (Analytical Chemistry) 1995 Mansoura University. Separation and determination of some metal ions As complexes Containing Phenylthiosemicarbazide Ph.D inorganic Chemistry (Ligational and Pharmacological application of Some nonsteroidal Antinflammotry drugs ) ( 2006).
Abstract: Cardiovascular diseases are the leading cause of morbidity in many countries worldwide. Antiplatelet
therapy has been successful in reducing mortality and morbidity in cardiovascular diseases. Because
inflammation is central to atherothrombosis, agents with both antiinflammatory and antithrombotic
properties may be critical to preventing the considerable morbidity and mortality associated with
atherothrombotic vascular disease including acute coronary syndrome (ACS), ischaemic stroke,
transient ischaemic attack (TIA). The purpose of developing a QSAR model is to reduce the cost of the
target designing by modifying the molecular structures for achieving the desired molecule with the
proposed property, without experimental measurement. In the current study, we extend a published
work that had been investiged the caffeic acid amides as antiplatelets aggregation and free radicals
scavenging agents. In this report, four equations were generated to predicate the biological activities
of these amide derivatives. Moreover, the biological activity for these molecules that was obtained
experimentally is compared with the calculated ones from QSAR output. Newly postulated compounds
were predicted as caffeic acid derivatives and their biological activity was deduced using QSAR. The
results showed that many of newly fourteen postulated compounds showed prominent biological
activities compared to the compounds investigated previously. Moreover, QSAR equations were useful
in predicating the biologic activity of the old and postulated molecules. Thus the newly caffeic acid
derivatives remain to be synthesized and investigated experimentally for their antiplatelet aggregation
and antioxidation properties. Finally, our results may be exhibited a potential interest for
investigators attempting to find new antiplatelets aggregation and free radicals scavenging agents.
